caa a22 4500 445352949 CHVBK 20180317142850.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00221-010-2511-0 doi (NATIONALLICENCE)springer-10.1007/s00221-010-2511-0 Non-invasive brain stimulation enhances fine motor control of the hemiparetic ankle: implications for rehabilitation [Elektronische Daten] [Sangeetha Madhavan, Kenneth Weber II, James Stinear] We set out to answer two questions with this study: 1. Can stroke patients improve voluntary control of their paretic ankle by practising a visuo-motor ankle-tracking task? 2. Are practice effects enhanced with non-invasive brain stimulation? A carefully selected sample of chronic stroke patients able to perform the experimental task attended three data collection sessions. Facilitatory transcranial direct current stimulation (tDCS) was applied in a random order over the lower limb primary motor cortex of the lesioned hemisphere or the non-lesioned hemisphere or sham stimulation was delivered over the lesioned hemisphere. In each session, tDCS was applied as patients practiced tracking a sinusoidal waveform for 15min using dorsiflexion-plantarflexion movements of their paretic ankle. The difference in tracking error prior to, and after, the 15min of practice was calculated. A practice effect was revealed following sham stimulation, and this effect was enhanced with tDCS applied over the lesioned hemisphere. The practice effect observed following sham stimulation was eliminated by tDCS applied over the non-lesioned hemisphere. The study provides the first evidence that non-invasive brain stimulation applied to the lesioned motor cortex of moderate- to well-recovered stroke patients enhances voluntary control of the paretic ankle. The results provide a basis for examining whether this enhanced ankle control can be induced in patients with greater impairments and whether enhanced control of a single or multiple lower limb joints improves hemiparetic gait patterns. Springer-Verlag, 2010 Stroke nationallicence Ankle nationallicence tDCS nationallicence TMS nationallicence Motor practice nationallicence Madhavan Sangeetha Department of Physical Therapy, University of Illinois, 1919 W Taylor St, 60612, Chicago, IL, USA aut Weber II Kenneth Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E. Superior Street, 60611, Chicago, IL, USA aut Stinear James Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E. Superior Street, 60611, Chicago, IL, USA aut Experimental Brain Research Springer-Verlag 209/1(2011-03-01), 9-17 0014-4819 209:1<9 2011 209 221 https://doi.org/10.1007/s00221-010-2511-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-010-2511-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madhavan Sangeetha Department of Physical Therapy, University of Illinois, 1919 W Taylor St, 60612, Chicago, IL, USA aut NATIONALLICENCE 700 1- Weber II Kenneth Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E. Superior Street, 60611, Chicago, IL, USA aut NATIONALLICENCE 700 1- Stinear James Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E. Superior Street, 60611, Chicago, IL, USA aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 209/1(2011-03-01), 9-17 0014-4819 209:1<9 2011 209 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer