caa a22 4500 445353007 CHVBK 20180317142850.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00221-011-2575-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2575-5 Cerebellar brain inhibition is decreased in active and surround muscles at the onset of voluntary movement [Elektronische Daten] [Panagiotis Kassavetis, Britt Hoffland, Tabish Saifee, Kailash Bhatia, Bart van de Warrenburg, John Rothwell, Mark Edwards] Highly selective activation of the desired muscles for each movement and inhibition of adjacent muscles is attributed to surround inhibition (SI) which differentially modulates corticospinal excitability in active and surrounding muscles. Cerebellar brain inhibition (CBI) is another inhibitory neuronal network which is known to be active at rest and during tonic muscle contraction. The way in which CBI may be modulated at movement onset and its relationship with SI has not previously been investigated. We assessed motor evoked potential (MEP) size and CBI in first dorsal interosseus (FDI) and abductor digiti minimi (ADM) muscles at rest and during a simple motor task where FDI was an active muscle and ADM was not involved in the movement (surround muscle). At onset of movement, MEP size in ADM was significantly suppressed, confirming the existence of SI. In contrast, CBI in both muscles was found to be significantly decreased at the onset of the movement. This was confirmed even after adjustments for changes in MEP size occurring due to onset of muscle activity in FDI and the effects of SI in ADM. Our findings fail to functionally link SI with CBI, but they do indicate a non-topographically specific modulation of CBI in association with initiation of voluntary movement. Springer-Verlag, 2011 TMS nationallicence Surround Inhibition nationallicence Cerebellar brain inhibition nationallicence Motor cortex nationallicence Movement nationallicence Kassavetis Panagiotis Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut Hoffland Britt Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut Saifee Tabish Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut Bhatia Kailash Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut van de Warrenburg Bart Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Rothwell John Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut Edwards Mark Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut Experimental Brain Research Springer-Verlag 209/3(2011-03-01), 437-442 0014-4819 209:3<437 2011 209 221 https://doi.org/10.1007/s00221-011-2575-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2575-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kassavetis Panagiotis Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Hoffland Britt Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Saifee Tabish Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Bhatia Kailash Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- van de Warrenburg Bart Department of Neurology, Donders Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Rothwell John Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Edwards Mark Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 209/3(2011-03-01), 437-442 0014-4819 209:3<437 2011 209 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer