caa a22 4500 445353120 CHVBK 20180317142851.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00221-011-2576-4 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2576-4 Effects of muscarinic receptor antagonism in the basolateral amygdala on two-way active avoidance [Elektronische Daten] [Anna Carballo-Márquez, Pere Boadas-Vaello, Irene Villarejo-Rodríguez, Gemma Guillazo-Blanch, Margarita Martí-Nicolovius, Anna Vale-Martínez] The aim of the present study was to investigate whether the blockade of muscarinic receptors (mRs) in the basolateral amygdala (BLA), which receives important cholinergic inputs related to avoidance learning, affects the consolidation of two-way active avoidance (TWAA). In Experiment 1, adult male Wistar rats were bilaterally infused with scopolamine (SCOP, 20μg/site) or PBS (VEH) in the BLA immediately after a single 30-trial acquisition session. Twenty-four hours later, avoidance retention was tested in an identical session. Results indicated that scopolamine in the BLA did not affect TWAA performance measured by the number of avoidance responses. Experiment 2 was conducted to test whether such a negative outcome might be due to the occurrence of overtraining during acquisition, which may indeed have a protective effect against scopolamine-induced memory deficits. In this experiment, rats were infused with scopolamine in the BLA immediately after a brief 10-trial acquisition session and tested 24h later in a 30-trial retention session. The SCOP group showed significantly more avoidances and inter-trial crossings in the retention session than the VEH rats. Together, these results reveal that mRs blockade in the BLA does not disrupt TWAA consolidation and may even enhance avoidance performance when infused after a low number of acquisition trials. Performance factors, such as locomotor activity in the shuttle-box, may account, at least in part, for the facilitative effects of muscarinic antagonism in the BLA. Springer-Verlag, 2011 Acetylcholine nationallicence Amygdala nationallicence Avoidance learning nationallicence Consolidation nationallicence Overtraining nationallicence Scopolamine nationallicence Carballo-Márquez Anna Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Boadas-Vaello Pere Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Villarejo-Rodríguez Irene Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Guillazo-Blanch Gemma Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Martí-Nicolovius Margarita Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Vale-Martínez Anna Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut Experimental Brain Research Springer-Verlag 209/3(2011-03-01), 455-464 0014-4819 209:3<455 2011 209 221 https://doi.org/10.1007/s00221-011-2576-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2576-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carballo-Márquez Anna Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Boadas-Vaello Pere Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Villarejo-Rodríguez Irene Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Guillazo-Blanch Gemma Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Martí-Nicolovius Margarita Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 700 1- Vale-Martínez Anna Department de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 209/3(2011-03-01), 455-464 0014-4819 209:3<455 2011 209 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer