caa a22 4500 445353333 CHVBK 20180317142851.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00221-011-2545-y doi (NATIONALLICENCE)springer-10.1007/s00221-011-2545-y Inactivation of the putamen selectively impairs reward history-based action selection [Elektronische Daten] [Manabu Muranishi, Hitoshi Inokawa, Hiroshi Yamada, Yasumasa Ueda, Naoyuki Matsumoto, Masanori Nakagawa, Minoru Kimura] Behavioral decisions and actions are directed to achieve specific goals and to obtain rewards and escape punishments. Previous studies involving the recording of neuronal activity suggest the involvement of the cerebral cortex, basal ganglia, and midbrain dopamine system in these processes. The value signal of the action options is represented in the striatum, updated by reward prediction errors, and used for selecting higher-value actions. However, it remains unclear whether dysfunction of the striatum leads to impairment of value-based action selection. The present study examined the effect of inactivation of the putamen via local injection of the GABAA receptor agonist muscimol in monkeys engaged in a manual reward-based multi-step choice task. The monkeys first searched a reward target from three alternatives, based on the previous one or two choices and their outcomes, and obtained a large reward; they then earned an additional reward by choosing the last rewarded target. Inactivation of the putamen impaired the ability of monkeys to make optimal choices during third trial in which they were required to choose a target different from those selected in the two previous trials by updating the values of the three options. The monkeys normally changed options if the last choice resulted in small reward (lose-shift) and stayed with the last choice if it resulted in large reward (win-stay). Task start time and movement time during individual trials became longer after putamen inactivation. But monkeys could control the motivation level depending on the reward value of individual trial types before and after putamen inactivation. These results support a view that the putamen is involved selectively and critically in neuronal circuits for reward history-based action selection. The Author(s), 2011 Putamen nationallicence Muscimol nationallicence Reward nationallicence Reinforcement learning nationallicence Decision-making nationallicence Muranishi Manabu Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Inokawa Hitoshi Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Yamada Hiroshi Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Ueda Yasumasa Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Matsumoto Naoyuki Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Nakagawa Masanori Department of Neurology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Kimura Minoru Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut Experimental Brain Research Springer-Verlag 209/2(2011-03-01), 235-246 0014-4819 209:2<235 2011 209 221 https://doi.org/10.1007/s00221-011-2545-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2545-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muranishi Manabu Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Inokawa Hitoshi Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamada Hiroshi Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Ueda Yasumasa Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Matsumoto Naoyuki Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Nakagawa Masanori Department of Neurology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 700 1- Kimura Minoru Department of Neurophysiology, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, 602-8566, Kyoto, Japan aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 209/2(2011-03-01), 235-246 0014-4819 209:2<235 2011 209 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer