caa a22 4500 44535349X CHVBK 20180317142852.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2697-9 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2697-9 Non-invasive stimulation of the vibrissal pad improves recovery of whisking function after simultaneous lesion of the facial and infraorbital nerves in rats [Elektronische Daten] [H. Bendella, S. Pavlov, M. Grosheva, A. Irintchev, S. Angelova, D. Merkel, N. Sinis, K. Kaidoglou, E. Skouras, S. Dunlop, Doychin Angelov] We have recently shown that manual stimulation of target muscles promotes functional recovery after transection and surgical repair to pure motor nerves (facial: whisking and blink reflex; hypoglossal: tongue position). However, following facial nerve repair, manual stimulation is detrimental if sensory afferent input is eliminated by, e.g., infraorbital nerve extirpation. To further understand the interplay between sensory input and motor recovery, we performed simultaneous cut-and-suture lesions on both the facial and the infraorbital nerves and examined whether stimulation of the sensory afferents from the vibrissae by a forced use would improve motor recovery. The efficacy of 3 treatment paradigms was assessed: removal of the contralateral vibrissae to ensure a maximal use of the ipsilateral ones (vibrissal stimulation; Group 2), manual stimulation of the ipsilateral vibrissal muscles (Group 3), and vibrissal stimulation followed by manual stimulation (Group 4). Data were compared to controls which underwent surgery but did not receive any treatment (Group 1). Four months after surgery, all three treatments significantly improved the amplitude of vibrissal whisking to 30° versus 11° in the controls of Group 1. The three treatments also reduced the degree of polyneuronal innervation of target muscle fibers to 37% versus 58% in Group 1. These findings indicate that forced vibrissal use and manual stimulation, either alone or sequentially, reduce target muscle polyinnervation and improve recovery of whisking function when both the sensory and the motor components of the trigemino-facial system regenerate. Springer-Verlag, 2011 Facial nerve nationallicence Trigeminal nerve nationallicence Regeneration nationallicence Manual stimulation nationallicence Vibrissal function nationallicence Bendella H. Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut Pavlov S. Department of Anatomy, Histology, Embryology, Medical University of Varna, Varna, Bulgaria aut Grosheva M. Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany aut Irintchev A. Department of Otorhinolaryngology, Friedrich-Schiller University Jena, Jena, Germany aut Angelova S. Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany aut Merkel D. Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut Sinis N. Plastic Surgery Clinic, Martin-Luther-Hospital, Berlin, Germany aut Kaidoglou K. Department of Histology and Embryology, Aristotle University of Thessaloniki, Thessaloniki, Greece aut Skouras E. Department of Orthopedics and Traumatology, University of Cologne, Cologne, Germany aut Dunlop S. School of Animal Biology, The University of Western Australia (M317), 6009, Crawley, WA, Australia aut Angelov Doychin Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut Experimental Brain Research Springer-Verlag 212/1(2011-07-01), 65-79 0014-4819 212:1<65 2011 212 221 https://doi.org/10.1007/s00221-011-2697-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2697-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bendella H. Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut NATIONALLICENCE 700 1- Pavlov S. Department of Anatomy, Histology, Embryology, Medical University of Varna, Varna, Bulgaria aut NATIONALLICENCE 700 1- Grosheva M. Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Irintchev A. Department of Otorhinolaryngology, Friedrich-Schiller University Jena, Jena, Germany aut NATIONALLICENCE 700 1- Angelova S. Department of Oto-Rhino-Laryngology, University of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Merkel D. Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut NATIONALLICENCE 700 1- Sinis N. Plastic Surgery Clinic, Martin-Luther-Hospital, Berlin, Germany aut NATIONALLICENCE 700 1- Kaidoglou K. Department of Histology and Embryology, Aristotle University of Thessaloniki, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Skouras E. Department of Orthopedics and Traumatology, University of Cologne, Cologne, Germany aut NATIONALLICENCE 700 1- Dunlop S. School of Animal Biology, The University of Western Australia (M317), 6009, Crawley, WA, Australia aut NATIONALLICENCE 700 1- Angelov Doychin Department of Anatomy I, Anatomical Institute at the University of Cologne, Joseph-Stelzmann-Street 9, 50924, Cologne, Germany aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/1(2011-07-01), 65-79 0014-4819 212:1<65 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer