caa a22 4500 445353503 CHVBK 20180317142852.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2700-5 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2700-5 Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects [Elektronische Daten] [P. Li Voti, A. Conte, A. Suppa, E. Iezzi, M. Bologna, M. Aniello, G. Defazio, J. Rothwell, Alfredo Berardelli] There is good evidence that synaptic plasticity in human motor cortex is involved in behavioural motor learning; in addition, it is now possible to probe mechanisms of synaptic plasticity using a variety of transcranial brain-stimulation protocols. Interactions between these protocols suggest that they both utilise common mechanisms. The aim of the present experiments was to test how well responsiveness to brain-stimulation protocols and behavioural motor learning correlate with each other in a sample of 21 healthy volunteers. We also examined whether any of these measures were influenced by the presence of a Val66Met polymorphism in the BDNF gene since this is another factor that has been suggested to be able to predict response to tests of synaptic plasticity. In 3 different experimental sessions, volunteers underwent 5-Hz rTMS, intermittent theta-burst stimulation (iTBS) and a motor learning task. Blood samples were collected from each subject for BDNF genotyping. As expected, both 5-Hz rTMS and iTBS significantly facilitated MEPs. Similarly, as expected, kinematic variables of finger movement significantly improved during the motor learning task. Although there was a significant correlation between the effect of iTBS and 5-Hz rTMS, there was no relationship in each subject between the amount of TMS-induced plasticity and the increase in kinematic variables during motor learning. Val66Val and Val66Met carriers did not differ in their response to any of the protocols. The present results emphasise that although some TMS measures of cortical plasticity may correlate with each other, they may not always relate directly to measures of behavioural learning. Similarly, presence of the Val66Met BDNF polymorphism also does not reliably predict responsiveness in small groups of individuals. Individual success in behavioural learning is unlikely to be closely related to any single measure of synaptic plasticity. Springer-Verlag, 2011 Cortical plasticity nationallicence 5-Hz rTMS nationallicence Theta burst stimulation nationallicence BDNF nationallicence Li Voti P. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut Conte A. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut Suppa A. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut Iezzi E. Neuromed Institute, I.R.C.C.S., Pozzilli (IS), Italy aut Bologna M. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut Aniello M. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut Defazio G. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut Rothwell J. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK aut Berardelli Alfredo Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut Experimental Brain Research Springer-Verlag 212/1(2011-07-01), 91-99 0014-4819 212:1<91 2011 212 221 https://doi.org/10.1007/s00221-011-2700-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2700-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Voti P. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Conte A. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Suppa A. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Iezzi E. Neuromed Institute, I.R.C.C.S., Pozzilli (IS), Italy aut NATIONALLICENCE 700 1- Bologna M. Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Aniello M. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Defazio G. Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Rothwell J. Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK aut NATIONALLICENCE 700 1- Berardelli Alfredo Department of Neurology and Psychiatry, "Sapienza”, University of Rome, Viale dell'Università, 30, 00185, Rome, Italy aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/1(2011-07-01), 91-99 0014-4819 212:1<91 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer