caa a22 4500 445353600 CHVBK 20180317142852.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2736-6 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2736-6 Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson's disease [Elektronische Daten] [Ignacio Obeso, Leonora Wilkinson, Enrique Casabona, Maria Bringas, Mario Álvarez, Lázaro Álvarez, Nancy Pavón, Maria-Cruz Rodríguez-Oroz, Raúl Macías, Jose Obeso, Marjan Jahanshahi] Recent imaging studies in healthy controls with a conditional stop signal reaction time (RT) task have implicated the subthalamic nucleus (STN) in response inhibition and the pre-supplementary motor area (pre-SMA) in conflict resolution. Parkinson's disease (PD) is characterized by striatal dopamine deficiency and overactivity of the STN and underactivation of the pre-SMA during movement. We used the conditional stop signal RT task to investigate whether PD produced similar or dissociable effects on response initiation, response inhibition and response initiation under conflict. In addition, we also examined inhibition of prepotent responses on three cognitive tasks: the Stroop, random number generation and Hayling sentence completion. PD patients were impaired on the conditional stop signal reaction time task, with response initiation both in situations with or without conflict and response inhibition all being significantly delayed, and had significantly greater difficulty in suppressing prepotent or habitual responses on the Stroop, Hayling and random number generation tasks relative to controls. These results demonstrate the existence of a generalized inhibitory deficit in PD, which suggest that PD is a disorder of inhibition as well as activation and that in situations of conflict, executive control over responses is compromised. Springer-Verlag, 2011 Fronto-striatal circuits nationallicence Parkinson's disease nationallicence Subthalamic nucleus nationallicence Inhibition nationallicence Stop signal task nationallicence Obeso Ignacio Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut Wilkinson Leonora Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut Casabona Enrique Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Bringas Maria Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Álvarez Mario Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Álvarez Lázaro Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Pavón Nancy Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Rodríguez-Oroz Maria-Cruz Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut Macías Raúl Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut Obeso Jose Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut Jahanshahi Marjan Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut Experimental Brain Research Springer-Verlag 212/3(2011-07-01), 371-384 0014-4819 212:3<371 2011 212 221 https://doi.org/10.1007/s00221-011-2736-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2736-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Obeso Ignacio Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Wilkinson Leonora Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 700 1- Casabona Enrique Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Bringas Maria Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Álvarez Mario Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Álvarez Lázaro Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Pavón Nancy Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Rodríguez-Oroz Maria-Cruz Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Macías Raúl Movement Disorders and Neurophysiology Units, Centro Internacional de Restauración Neurológica (CIREN), La Habana, Cuba aut NATIONALLICENCE 700 1- Obeso Jose Department of Neurology, Clínica Universitaria and Medical School of Navarra, Neuroscience Centre, CIMA, University of Navarra, Pamplona, Spain aut NATIONALLICENCE 700 1- Jahanshahi Marjan Cognitive-Motor Neuroscience Group, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology and Neurosurgery, 33 Queen Square, WC1N 3BG, London, UK aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/3(2011-07-01), 371-384 0014-4819 212:3<371 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer