caa a22 4500 445353643 CHVBK 20180317142852.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2750-8 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2750-8 Modulation of the soleus H reflex by electrical subcortical stimuli in humans [Elektronische Daten] [João Costa, Jessica Guzmán, Francesc Valldeoriola, Jordi Rumià, Eduardo Tolosa, Jordi Casanova-Molla, Josep Valls-Solé] Over the past two decades, the H reflex has been used as a neural tool to assess the effect on the motoneuronal pool of conditioning volleys in supraspinal descending tracts elicited by transcranial magnetic stimulation (TMS) or auditory stimuli. However, mechanisms mediating such modulation are unclear. These hypothesized neural pathways are likely to be affected by single electrical stimulus applied through the electrodes implanted in the subthalamic nucleus for deep brain stimulation (sSTNDBS). To improve our knowledge on such mechanisms, we examined in 11 Parkinson's disease patients the effects of conditioning sSTNDBS applied contralateral and ipsilateral to the H reflex recording on the amplitude of the soleus H reflex, at interstimulus intervals (ISIs) between 0 and 110ms. There was a significant main effect of the ISI (P<0.001) and of the sSTNDBS stimulation side (P=0.019) on the percentage change in the soleus H-reflex amplitude. Contralateral sSTNDBS modulation of the soleus H reflex resembles that of TMS in healthy subjects with two facilitation phases (at 5-20ms and at 60ms), while after ipsilateral sSTNDBS, there is only a single facilitation phase peaking up at 5ms later than the first facilitation period observed with contralateral stimulation. These findings contribute to the discussion of the mechanisms underlying the excitability of the spinal alpha motoneuron pool and the modulation of the H reflex by supraspinal stimuli. Springer-Verlag, 2011 Neural pathways nationallicence Subthalamic nucleus nationallicence Deep brain stimulation nationallicence Interstimuli interval nationallicence Costa João EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut Guzmán Jessica EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut Valldeoriola Francesc Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Barcelona, Spain aut Rumià Jordi Neurosurgery Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain aut Tolosa Eduardo Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Barcelona, Spain aut Casanova-Molla Jordi EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut Valls-Solé Josep EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut Experimental Brain Research Springer-Verlag 212/3(2011-07-01), 439-448 0014-4819 212:3<439 2011 212 221 https://doi.org/10.1007/s00221-011-2750-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2750-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Costa João EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Guzmán Jessica EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Valldeoriola Francesc Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Barcelona, Spain aut NATIONALLICENCE 700 1- Rumià Jordi Neurosurgery Department, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain aut NATIONALLICENCE 700 1- Tolosa Eduardo Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Barcelona, Spain aut NATIONALLICENCE 700 1- Casanova-Molla Jordi EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Valls-Solé Josep EMG and Motor Control Unit, Neurology Department, Hospital Clínic, Universitat de Barcelona, IDIBAPS (Institut d'Investigació Biomèdica August Pi i Sunyer), Villarroel, 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/3(2011-07-01), 439-448 0014-4819 212:3<439 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer