caa a22 4500 445353791 CHVBK 20180317142853.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00221-011-2771-3 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2771-3 Inter-individual discount factor differences in reward prediction are topographically associated with caudate activation [Elektronische Daten] [Keiichi Onoda, Yasumasa Okamoto, Yoshihiko Kunisato, Siori Aoyama, Kazuhiro Shishida, Go Okada, Saori Tanaka, Nicolas Schweighofer, Shuhei Yamaguchi, Kenji Doya, Shigeto Yamawaki] In general, humans tend to devalue a delayed reward. Such delay discounting is a theoretical and computational concept in which the discount factor influences the time scale of the trade-off between delay of reward and amount of reward. The discount factor relies on the individual's ability to evaluate the future reward. Using functional magnetic resonance imaging, we investigated brain mechanisms for reward valuation at different individual discount factors in a delayed reward choice task. In the task, participants were required to select small/immediate or large/delayed rewards to maximize the total reward over time. The discount factor for each participant individually was calculated from the behavioral data based on an exponential discounting model. The estimated value of a future reward increases as the expected delivery approaches, so the time course of these estimated values was computed based on each individual's discount factor; each was entered into the regression analysis as an explanatory (independent) variable. After the region of interest was narrowed anatomically to the caudate, a peak coordinate was detected in each individual. A correlation analysis revealed that the location of the peak along the dorsal-ventral axis in the right caudate was positively correlated with the discount factor. This implies that individuals who showed a larger discount factor had peak activations in a more dorsal part of the right caudate associated with future reward prediction. This evidence also suggests that a higher ability to delay reward prediction might be related to activation of the more dorsal caudate. Springer-Verlag, 2011 Delayed reward nationallicence Delay discounting nationallicence Caudate nationallicence Individual difference nationallicence fMRI nationallicence Onoda Keiichi Department of Neurology, Shimane University, Shimane, Japan aut Okamoto Yasumasa Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Kunisato Yoshihiko Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Aoyama Siori Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Shishida Kazuhiro Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Okada Go Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Tanaka Saori Institute of Social and Economic Research, Osaka University, Osaka, Japan aut Schweighofer Nicolas Department of Physical Therapy and Biokinesiology, University of Southern California, Los Angeles, CA, USA aut Yamaguchi Shuhei Department of Neurology, Shimane University, Shimane, Japan aut Doya Kenji Department of Computational Neurobiology, Advanced Telecommunication Research Institute International, Kyoto, Japan aut Yamawaki Shigeto Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut Experimental Brain Research Springer-Verlag 212/4(2011-08-01), 593-601 0014-4819 212:4<593 2011 212 221 https://doi.org/10.1007/s00221-011-2771-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2771-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Onoda Keiichi Department of Neurology, Shimane University, Shimane, Japan aut NATIONALLICENCE 700 1- Okamoto Yasumasa Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Kunisato Yoshihiko Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Aoyama Siori Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Shishida Kazuhiro Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Okada Go Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 700 1- Tanaka Saori Institute of Social and Economic Research, Osaka University, Osaka, Japan aut NATIONALLICENCE 700 1- Schweighofer Nicolas Department of Physical Therapy and Biokinesiology, University of Southern California, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Yamaguchi Shuhei Department of Neurology, Shimane University, Shimane, Japan aut NATIONALLICENCE 700 1- Doya Kenji Department of Computational Neurobiology, Advanced Telecommunication Research Institute International, Kyoto, Japan aut NATIONALLICENCE 700 1- Yamawaki Shigeto Department of Psychiatry and Neurosciences, Division of Frontier Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, 734-8551, Hiroshima, Japan aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/4(2011-08-01), 593-601 0014-4819 212:4<593 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer