caa a22 4500 445353945 CHVBK 20180317142853.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2718-8 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2718-8 Heterotopic low-frequency stimulation induces nociceptive LTD within the same central receptive field in man [Elektronische Daten] [Kerstin Jung, Lars Larsen, Silke Rottmann, Jens Ellrich] Electrical low-frequency stimulation (LFS) evokes long-term depression (LTD) of nociception. Human studies suggested a strictly homotopic organization. This study hypothesizes that even heterotopic LFS evokes LTD within the same receptive field (RF). In 33 healthy volunteers, painful electrical test stimulation and LFS were applied to the low back by a concentric electrode (ExpBack) and to the forearm by a multiarray electrode (ExpArm). Volunteers rated pain perception during test stimulation that was applied before and after LFS. In ExpBack, test stimuli were administered within the right T12 dermatome. LFS was applied heterotopically within the same RF or remote in dermatome T8. In ExpArm, test stimulation was carried out in the center of the RF whereas LFS was applied to the center, margin, or outside the RF. In ExpBack (n=20), pain ratings decreased significantly stronger in T12 than in T8 dermatome (P<0.01). In ExpArm (n=20), LFS to the center of the RF induced a stronger pain reduction than LFS applied outside the RF (P<0.001). This study demonstrates a heterosynaptic organization of LTD within the same RF. Profound knowledge about RF involvement on LTD seems crucial in order to judge the quality of LFS as a possible neuromodulatory treatment of pain. Springer-Verlag, 2011 Concentric electrode nationallicence Pain perception nationallicence Plasticity nationallicence Spinal system nationallicence 2PD : Two-point discrimination test nationallicence cRF : Central receptive field nationallicence ExpArm : Experiments performed on the forearm nationallicence ExpBack : Experiments performed on the low back region nationallicence IE : Inner electrode nationallicence IP : Pain threshold nationallicence IS : Stimulus intensity nationallicence LFS : Low-frequency stimulation nationallicence LTD : Long-term depression nationallicence ME : Master electrode nationallicence mRF : Marginal receptive field nationallicence OE : Outer electrode nationallicence oRF : Outlying receptive field nationallicence RF : Receptive field nationallicence ROI : Region of interest nationallicence Jung Kerstin Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut Larsen Lars Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut Rottmann Silke Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut Ellrich Jens Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut Experimental Brain Research Springer-Verlag 212/2(2011-07-01), 189-198 0014-4819 212:2<189 2011 212 221 https://doi.org/10.1007/s00221-011-2718-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2718-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Kerstin Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut NATIONALLICENCE 700 1- Larsen Lars Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut NATIONALLICENCE 700 1- Rottmann Silke Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut NATIONALLICENCE 700 1- Ellrich Jens Medical Physiology and Experimental Pharmacology Group, Center for Sensory-Motor Interaction SMI, Department of Health Science and Technology, Medical Faculty, Aalborg University, Fredrik Bajers Vej 7D2, 9220, Aalborg, Denmark aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/2(2011-07-01), 189-198 0014-4819 212:2<189 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer