caa a22 4500 445354011 CHVBK 20180317142853.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00221-011-2725-9 doi (NATIONALLICENCE)springer-10.1007/s00221-011-2725-9 The influence of cues and stimulus history on the non-linear frequency characteristics of the pursuit response to randomized target motion [Elektronische Daten] [Graham Barnes, C. Collins] When humans pursue motion stimuli composed of alternating constant velocity segments of randomised duration (RD), they nevertheless initiate anticipatory eye deceleration before stimulus direction changes at a pre-programmed time based on averaging prior stimulus timing. We investigated, in both the time and frequency domains, how averaging interacts with deceleration cues by comparing responses to stimuli composed of segments that were either constant-velocity ramps or half-cycle sinusoids. RDs were randomized within 6 ranges, each comprising 8 RDs and having differing mean RD. In sine responses, deceleration cues could be used to modulate eye velocity for long-range stimuli (RD=840-1,200ms) but in the shortest range (RD=240-660ms) cues became ineffective, so that sine responses resembled ramp responses, and anticipatory timing was primarily dependent on averaging. Additionally, inclusion of short duration (240ms) segments reduced peak eye velocity for all RDs within a range, even when longer RDs in the range (up to 1,080ms) would normally elicit much higher velocities. These effects could be attributed to antagonistic interactions between visually driven pursuit components and pre-programmed anticipatory deceleration components. In the frequency domain, the changes in peak velocity and anticipatory timing with RD range were translated into non-linear gain and phase characteristics similar to those evoked by sum-of-sines stimuli. Notably, a reduction in pursuit gain occurred when high-frequency components associated with short duration segments were present. Results appear consistent with an adapted pursuit model, in which pre-programmed timing information derived from an internally reconstructed stimulus signal is stored in short-term memory and controls the initiation of predictive responses. Springer-Verlag, 2011 Eye movements nationallicence Pursuit nationallicence Expectation nationallicence Prediction nationallicence Frequency response nationallicence Humans nationallicence Barnes Graham Faculty of Life Sciences, University of Manchester, M60 1QD, Manchester, UK aut Collins C. Faculty of Life Sciences, University of Manchester, M60 1QD, Manchester, UK aut Experimental Brain Research Springer-Verlag 212/2(2011-07-01), 225-240 0014-4819 212:2<225 2011 212 221 https://doi.org/10.1007/s00221-011-2725-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-011-2725-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Barnes Graham Faculty of Life Sciences, University of Manchester, M60 1QD, Manchester, UK aut NATIONALLICENCE 700 1- Collins C. Faculty of Life Sciences, University of Manchester, M60 1QD, Manchester, UK aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 212/2(2011-07-01), 225-240 0014-4819 212:2<225 2011 212 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer