caa a22 4500 445354054 CHVBK 20180317142854.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00221-010-2432-y doi (NATIONALLICENCE)springer-10.1007/s00221-010-2432-y Impaired conflict monitoring in Parkinson's disease patients during an oculomotor redirect task [Elektronische Daten] [Ausaf Farooqui, Neha Bhutani, Shrikanth Kulashekhar, Madhuri Behari, Vinay Goel, Aditya Murthy] Fallibility is inherent in human cognition and so a system that will monitor performance is indispensable. While behavioral evidence for such a system derives from the finding that subjects slow down after trials that are likely to produce errors, the neural and behavioral characterization that enables such control is incomplete. Here, we report a specific role for dopamine/basal ganglia in response conflict by accessing deficits in performance monitoring in patients with Parkinson's disease. To characterize such a deficit, we used a modification of the oculomotor countermanding task to show that slowing down of responses that generate robust response conflict, and not post-error per se, is deficient in Parkinson's disease patients. Poor performance adjustment could be either due to impaired ability to slow RT subsequent to conflicts or due to impaired response conflict recognition. If the latter hypothesis was true, then PD subjects should show evidence of impaired error detection/correction, which was found to be the case. These results make a strong case for impaired performance monitoring in Parkinson's patients. Springer-Verlag, 2010 Conflicts nationallicence Error correction nationallicence Saccades nationallicence Basal ganglia nationallicence Double-step nationallicence Countermanding nationallicence Farooqui Ausaf National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut Bhutani Neha National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut Kulashekhar Shrikanth National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut Behari Madhuri Department of Neurology, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Goel Vinay Department of Neurology, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Murthy Aditya National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut Experimental Brain Research Springer-Verlag 208/1(2011-01-01), 1-10 0014-4819 208:1<1 2011 208 221 https://doi.org/10.1007/s00221-010-2432-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-010-2432-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farooqui Ausaf National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut NATIONALLICENCE 700 1- Bhutani Neha National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut NATIONALLICENCE 700 1- Kulashekhar Shrikanth National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut NATIONALLICENCE 700 1- Behari Madhuri Department of Neurology, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Goel Vinay Department of Neurology, CN Centre, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Murthy Aditya National Brain Research Centre, Near NSG Campus, Nainwal More, 122050, Manesar, HR, India aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 208/1(2011-01-01), 1-10 0014-4819 208:1<1 2011 208 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer