caa a22 4500 445354488 CHVBK 20180317142855.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00221-010-2473-2 doi (NATIONALLICENCE)springer-10.1007/s00221-010-2473-2 Modulation of corticomotor excitability by an I-wave intervention delivered during low-level voluntary contraction [Elektronische Daten] [B. Silbert, J. Gibbons, R. Cash, F. Mastaglia, G. Thickbroom] Transcranial magnetic stimulation (TMS) interventions that modulate cortical plasticity may achieve a more functional benefit if combined with neuro-rehabilitation therapies. With a TMS protocol targeting I-wave dynamics, it is possible to deliver stimuli while a subject performs a motor task, and this may more effectively target functional networks related to the task. However, the efficacy of this intervention during a simple task such as a low-level voluntary contraction is not known. We delivered paired-pulse TMS at an inter-pulse interval (IPI) of 1.5ms for 15min while subjects performed a 10±2.5% voluntary contraction of the first dorsal interosseous (FDI) muscle and made motor evoked potential (MEP) amplitude and short-interval intracortical facilitation (SICF) curve measurements. Pre-intervention SICF curves showed only a single peak at 1.3-1.5ms IPI. During the intervention, MEP amplitude steadily increased (P<0.001) to 137±13% of its initial value. After the intervention, SICF curves were increased in amplitude (P<0.001) and later peaks emerged at 2.8 and 4.3ms IPIs. A control experiment, replacing paired-pulse stimulation with single-pulse stimulation showed no effect on MEP amplitude (P=0.951). We conclude that the I-wave intervention can be administered concurrently with a simple motor task and that it acts by increasing trans-synaptic efficacy across a number of I-waves. The ability to perform a motor task simultaneously with a TMS intervention could confer a degree of specificity to the induced excitability changes and may be beneficial for functional neuro-rehabilitation programs built around motor learning and retraining. Springer-Verlag, 2010 TMS nationallicence SICF nationallicence Intervention nationallicence Voluntary contraction nationallicence Silbert B. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut Gibbons J. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut Cash R. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut Mastaglia F. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut Thickbroom G. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut Experimental Brain Research Springer-Verlag 208/2(2011-01-01), 229-235 0014-4819 208:2<229 2011 208 221 https://doi.org/10.1007/s00221-010-2473-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00221-010-2473-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silbert B. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut NATIONALLICENCE 700 1- Gibbons J. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut NATIONALLICENCE 700 1- Cash R. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut NATIONALLICENCE 700 1- Mastaglia F. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut NATIONALLICENCE 700 1- Thickbroom G. Centre for Neuromuscular and Neurological Disorders, M518, University of Western Australia, 6009, Nedlands, WA, Australia aut NATIONALLICENCE 773 0- Experimental Brain Research Springer-Verlag 208/2(2011-01-01), 229-235 0014-4819 208:2<229 2011 208 221 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer