caa a22 4500 445354682 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10238-010-0102-9 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0102-9 Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia [Elektronische Daten] [Pan-pan Cheng, Xiao-yang Jiao, Xue-hua Wang, Jing-hua Lin, Ying-mu Cai] Hepcidin is a key hormone governing mammalian iron homeostasis and may be directly or indirectly involved in the development of most iron deficiency/overload and inflammation-induced anemia. The objective of this study was to investigate the expression of hepcidin in anemia of chronic disease. To characterize serum hepcidin, iron and inflammatory indicators associated with anemia of chronic disease (ACD), we studied ACD, ACD concomitant iron-deficiency anemia (ACD/IDA), pure IDA and acute inflammation (AcI) patients and analyzed the associations between hepcidin levels and inflammation parameters in various types of anemia. Serum hepcidin levels in patient groups were statistically different, from high to low: ACD, AcI>ACD/IDA>the control>IDA. Serum ferritin levels were significantly increased in ACD and AcI patients but were decreased significantly in ACD/IDA and IDA. Elevated serum EPO concentrations were found in ACD, ACD/IDA and IDA patients but not in AcI patients and the controls. A positive correlation between hepcidin and IL-6 levels only existed in ACD/IDA, AcI and the control groups. A positive correlation between hepcidin and ferritin was marked in the control group, while a negative correlation between hepcidin and ferritin was noted in IDA. The significant negative correlation between hepcidin expression and reticulocyte count was marked in both ACD/IDA and IDA groups. All of these data demonstrated that hepcidin might play role in pathogenesis of ACD, ACD/IDA and IDA, and it could be a potential marker for detection and differentiation of these anemias. Springer-Verlag, 2010 Anemia of chronic disease nationallicence Iron-deficiency anemia nationallicence Hepcidin nationallicence Erythropoietin nationallicence IL-6 nationallicence Cheng Pan-pan Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut Jiao Xiao-yang Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut Wang Xue-hua Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut Lin Jing-hua Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut Cai Ying-mu Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut Clinical and Experimental Medicine Springer Milan 11/1(2011-03-01), 33-42 1591-8890 11:1<33 2011 11 10238 https://doi.org/10.1007/s10238-010-0102-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0102-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cheng Pan-pan Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut NATIONALLICENCE 700 1- Jiao Xiao-yang Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut NATIONALLICENCE 700 1- Wang Xue-hua Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut NATIONALLICENCE 700 1- Lin Jing-hua Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut NATIONALLICENCE 700 1- Cai Ying-mu Department of Hemotology Laboratory, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, 515041, Shantou, Guangdong, China aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/1(2011-03-01), 33-42 1591-8890 11:1<33 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer