caa a22 4500 445354690 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10238-010-0124-3 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0124-3 Hypocholesterolemia is associated negatively with hemolysate lipid peroxidation in sickle cell anemia patients [Elektronische Daten] [Oztas Yesim, Sabuncuoglu Suna, Unal Selma, Ozgunes Hilal, Ozgunes Nuriman] The oxidative stress levels in plasma and hemolysate and cholesterol levels in plasma of sickle cell anemia patients, carriers and controls were evaluated. A total of 40 cases—17 patients, 13 carriers and 10 controls—were involved in the study. Plasma and hemolysate malondialdehyde (MDA) were detected via thiobarbituric acid reaction with a fluorimetric detector by high-performance liquid chromatography system. Plasma cholesterol was determined by enzymatic colorimetric method. Mean MDA levels of SCA patients were higher than those of the carriers' and healthy children's both in plasma and in hemolysate (P<0.005). The mean plasma and hemolysate MDA levels were 25.3±1.6nmol/l and 86.7±19.3nmol/l in patients, 19.1±0.8nmol/l and 54.1±10.8nmol/l in carriers and 19.6±0.8nmol/l and 56.8±9.3nmol/l in healthy children. Mean plasma total cholesterol levels were 92.1±19.1mg/dl in patients, 116.2±23.3mg/dl in carriers and 126.6±16.4mg/dl in controls (P<0.005). There was a significant negative correlation of −0.520 between hemolysate MDA and plasma cholesterol levels in patients (P<0.05). The degree of correlation increased up to −0.782 (P=0.008) in the patients with HbSS phenotype. This negative correlation between MDA and cholesterol may imply a potential association between oxidative stress and hypocholesterolemia in sickle cell anemia. Springer-Verlag, 2010 Sickle cell nationallicence Anemia nationallicence Oxidative stress nationallicence MDA nationallicence Cholesterol nationallicence Yesim Oztas Faculty of Medicine, Department of Clinical Biochemistry, Hacettepe University, Rektorluk Binası, Kat: 3 Sihhiye, Ankara, Turkey aut Suna Sabuncuoglu Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Ankara, Turkey aut Selma Unal Faculty of Medicine, Department of Pediatrics, Hematology Unit, Mersin University, Mersin, Turkey aut Hilal Ozgunes Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Ankara, Turkey aut Nuriman Ozgunes Faculty of Medicine, Department of Clinical Biochemistry, Hacettepe University, Rektorluk Binası, Kat: 3 Sihhiye, Ankara, Turkey aut Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 195-198 1591-8890 11:3<195 2011 11 10238 https://doi.org/10.1007/s10238-010-0124-3 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0124-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yesim Oztas Faculty of Medicine, Department of Clinical Biochemistry, Hacettepe University, Rektorluk Binası, Kat: 3 Sihhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Suna Sabuncuoglu Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Ankara, Turkey aut NATIONALLICENCE 700 1- Selma Unal Faculty of Medicine, Department of Pediatrics, Hematology Unit, Mersin University, Mersin, Turkey aut NATIONALLICENCE 700 1- Hilal Ozgunes Faculty of Pharmacy, Department of Toxicology, Hacettepe University, Ankara, Turkey aut NATIONALLICENCE 700 1- Nuriman Ozgunes Faculty of Medicine, Department of Clinical Biochemistry, Hacettepe University, Rektorluk Binası, Kat: 3 Sihhiye, Ankara, Turkey aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 195-198 1591-8890 11:3<195 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer