caa a22 4500 445354712 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10238-010-0117-2 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0117-2 Osteoclastogenesis and arthritis [Elektronische Daten] [Nicola Maruotti, Maria Grano, Silvia Colucci, Francesca d'Onofrio, Francesco Cantatore] There is emerging interest for osteoclasts as key players in the erosive and inflammatory events leading to joint destruction in chronic arthritis. In fact, chronic inflammatory joint diseases such as psoriatic arthritis and rheumatoid arthritis are often characterized by destruction of juxta-articular bone and erosions due to the elevated activity of osteoclasts, which are involved in bone resorption. The main step in inflammatory bone erosion is an imbalance between bone resorption and bone formation: osteoclast formation is enhanced by proinflammatory cytokines such as TNF-α, IL-1β, and IL-17 and is not balanced by increased activity of bone-forming osteoblasts. T-cells, stromal cells, and synoviocytes enhance osteoclast formation via expression of RANKL and, under pathologic conditions, of proinflammatory cytokines. In rheumatoid arthritis, accumulation of osteoclasts in synovial tissues and their activation associated with osteoclastogenic cytokines and chemokines at cartilage erosion sites suggest that they could be usefully selected as therapeutic target. In particular, in consideration of the primary role of RANKL and TNF-α in osteoclastogenesis, the control of the production of RANKL and the inhibition of TNF-α represent important strategies for reducing bone damage in this disease. Springer-Verlag, 2010 Arthritis nationallicence Cytokines nationallicence Chemokines nationallicence Osteoclast nationallicence RANKL nationallicence TNF-α nationallicence Maruotti Nicola Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut Grano Maria Department of Human Anatomy and Histology "Rodolfo Amprino”, University of Bari, Bari, Italy aut Colucci Silvia Department of Human Anatomy and Histology "Rodolfo Amprino”, University of Bari, Bari, Italy aut d'Onofrio Francesca Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut Cantatore Francesco Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 137-145 1591-8890 11:3<137 2011 11 10238 https://doi.org/10.1007/s10238-010-0117-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0117-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maruotti Nicola Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut NATIONALLICENCE 700 1- Grano Maria Department of Human Anatomy and Histology "Rodolfo Amprino”, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- Colucci Silvia Department of Human Anatomy and Histology "Rodolfo Amprino”, University of Bari, Bari, Italy aut NATIONALLICENCE 700 1- d'Onofrio Francesca Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut NATIONALLICENCE 700 1- Cantatore Francesco Department of Rheumatology, University of Foggia Medical School, Foggia, Italy aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 137-145 1591-8890 11:3<137 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer