caa a22 4500 445354755 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10238-010-0122-5 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0122-5 Survivin -31C/G polymorphism and gastric cancer risk in a Brazilian population [Elektronische Daten] [Bárbara do Borges, Rommel Burbano, Maria Harada] Gastric cancer, despite its decline in incidence, remains a public health problem worldwide, especially in Brazil, where higher incidence indexes are still described. The Survivin gene codifies a multifunctional protein involved in the regulation of the cell cycle and inhibition of the apoptotic pathway, and a polymorphism (-31C/G) located in its promoter region is associated with gene regulation. In order to evaluate the correlation of this polymorphism with gastric cancer risk in a northern Brazil population, we sequenced a fragment containing the polymorphism in individuals with gastric cancer and controls. We observed no differences of alleles and genotype frequencies between cases and controls. However, G carriers of the tumor group had an increased relative risk of developing tumors of diffuse type (OR: 2.22—IC 95%: 0.4835-10.2137), localized in the antrum (OR: 2.16—IC 95%: 0.4811-9.6971) and in younger patients (<50years-old) (OR: 3.65—IC 95%: 0.4012-33.2429), although with no statistical significance. Nevertheless, C carriers with a high D17S250 microsatellite instability (TP53 gene) show a higher risk to develop gastric tumors (P=0.0453; OR: 4.1556—IC95%: 0.9716-17.7728), suggesting that the mutate TP53 gene may fail in control and inhibition of Survivin expression, favoring the gastric carcinogenesis. The present result suggests that the presence of the C allele of -31C/G Survivin promoter polymorphism in combination with D17S250 instability may be used as a risk factor for gastric cancer in our population. However, other studies based on a larger sample size are required to properly assess such hypothesis. Springer-Verlag, 2010 Survivin nationallicence Polymorphism nationallicence Gastric cancer nationallicence Brazil nationallicence Borges Bárbara do Laboratório de Biologia Molecular "Francisco Mauro Salzano”, Instituto de Ciências Biológicas, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Netto, Rua Augusto Correa, 01, 66075-970, Belém, Pará, Brazil aut Burbano Rommel Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil aut Harada Maria Laboratório de Biologia Molecular "Francisco Mauro Salzano”, Instituto de Ciências Biológicas, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Netto, Rua Augusto Correa, 01, 66075-970, Belém, Pará, Brazil aut Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 189-193 1591-8890 11:3<189 2011 11 10238 https://doi.org/10.1007/s10238-010-0122-5 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0122-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Borges Bárbara do Laboratório de Biologia Molecular "Francisco Mauro Salzano”, Instituto de Ciências Biológicas, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Netto, Rua Augusto Correa, 01, 66075-970, Belém, Pará, Brazil aut NATIONALLICENCE 700 1- Burbano Rommel Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil aut NATIONALLICENCE 700 1- Harada Maria Laboratório de Biologia Molecular "Francisco Mauro Salzano”, Instituto de Ciências Biológicas, Universidade Federal do Pará, Cidade Universitária Prof. José da Silveira Netto, Rua Augusto Correa, 01, 66075-970, Belém, Pará, Brazil aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/3(2011-09-01), 189-193 1591-8890 11:3<189 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer