caa a22 4500 445354771 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10238-010-0120-7 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0120-7 Lymphocyte subpopulation and dendritic cell phenotyping during antineoplastic therapy in human solid tumors [Elektronische Daten] [Sara Mariucci, Bianca Rovati, Mariangela Manzoni, Matteo Della Porta, Giuditta Comolli, Sara Delfanti, Marco Danova] Patients with cancer show variable levels of immunosuppression at the time of the presentation, and cytotoxic antineoplastic therapy is the primary contributor to the clinical immunodeficiency often observed during the course of the disease. In both hematological and solid tumors, this phenomenon is primarily related to the T-cell depletion associated with inhibition of dendritic cell ability to induce both primary and secondary T- and B-cell responses. Complete restoration of immunocompetence following antineoplastic therapy implicates the progressive recovery of various cell subpopulations, and it is a complex process that also depends on the type, the dose, the scheduling, and the associations of the employed drugs. In the era of target therapies, several antiangiogenic drugs are increasingly used in combination with standard chemotherapy in the treatment of advanced solid tumors. Their clinical efficacy has been recently related not only to the specific antiangiogenic properties but also to an indirect hypothetical effect on the host immune system. In the present work, we have reviewed the most recent information regarding (1) the capacity of standard antineoplastic therapy to induce and maintain an immunodeficiency in patients with solid tumors and (2) the influence of the antiangiogenic treatment in association with standard chemotherapy on lymphocyte and dendritic cell subsets and the possible resulting additional antitumor mechanism. Springer-Verlag, 2010 Lymphocyte subsets nationallicence Dendritic cells nationallicence Antineoplastic therapy nationallicence Angiogenesis nationallicence Solid tumors nationallicence Mariucci Sara S.C. Oncologia Medica, Laboratorio di Citofluorimetria e Terapie Cellulari, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Rovati Bianca S.C. Oncologia Medica, Laboratorio di Citofluorimetria e Terapie Cellulari, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Manzoni Mariangela S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Della Porta Matteo Istituto di Ematologia, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Comolli Giuditta S.C. Virologia e Microbiologia, Laboratori Sperimentali di Ricerca, Area Biotecnologie, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Delfanti Sara S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Danova Marco S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut Clinical and Experimental Medicine Springer Milan 11/4(2011-12-01), 199-210 1591-8890 11:4<199 2011 11 10238 https://doi.org/10.1007/s10238-010-0120-7 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0120-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mariucci Sara S.C. Oncologia Medica, Laboratorio di Citofluorimetria e Terapie Cellulari, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Rovati Bianca S.C. Oncologia Medica, Laboratorio di Citofluorimetria e Terapie Cellulari, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Manzoni Mariangela S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Della Porta Matteo Istituto di Ematologia, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Comolli Giuditta S.C. Virologia e Microbiologia, Laboratori Sperimentali di Ricerca, Area Biotecnologie, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Delfanti Sara S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 700 1- Danova Marco S.C. Oncologia Medica, Fondazione IRCCS Policlinico San Matteo e Università di Pavia, Viale Golgi, 19, 27100, Pavia, Italy aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/4(2011-12-01), 199-210 1591-8890 11:4<199 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer