caa a22 4500 44535478X CHVBK 20180317142856.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10238-010-0127-0 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0127-0 SOX2 gene expression in normal human thymus and thymoma [Elektronische Daten] [Anca Cimpean, Svetlana Encica, Marius Raica, Domenico Ribatti] The SOX gene family encodes a large group of transcription factors that are strongly involved in the normal human development and malignancies. Human tumors, like small cell lung carcinoma, meningioma, gastric, and pancreatic cancer, have been found to be immunogenic for SOX2 protein. In this study, we have investigated for the first time the expression and distribution of SOX2 immunoreactive cells in five normal human thymuses (2 fetal and 3 adult) and 10 thymomas bioptic specimens. Results demonstrated the presence of few positive cells in the fetal and postnatal normal human thymus with a specific distribution within thymus parenchyma compartments. On the contrary, in thymoma immunoreactivity to SOX2 increased parallel to pathological stage, and a peculiar distribution was observed in type B3 thymoma with a positive reaction in both tumor and endothelial cells. Springer-Verlag, 2010 Human thymus nationallicence Immunohistochemistry nationallicence SOX2 nationallicence Thymoma nationallicence Cimpean Anca Department of Histology, "Victor Babeş” University of Medicine and Pharmacy, Timişoara, Romania aut Encica Svetlana Department of Pathology, "Niculae Stăncioiu” Heart Institute, Cluj Napoca, Romania aut Raica Marius Department of Histology, "Victor Babeş” University of Medicine and Pharmacy, Timişoara, Romania aut Ribatti Domenico Department of Human Anatomy and Histology, School of Medicine, University of Bari Medical School, Piazza G. Cesare, 11 Policlinico, 70124, Bari, Italy aut Clinical and Experimental Medicine Springer Milan 11/4(2011-12-01), 251-254 1591-8890 11:4<251 2011 11 10238 https://doi.org/10.1007/s10238-010-0127-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0127-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cimpean Anca Department of Histology, "Victor Babeş” University of Medicine and Pharmacy, Timişoara, Romania aut NATIONALLICENCE 700 1- Encica Svetlana Department of Pathology, "Niculae Stăncioiu” Heart Institute, Cluj Napoca, Romania aut NATIONALLICENCE 700 1- Raica Marius Department of Histology, "Victor Babeş” University of Medicine and Pharmacy, Timişoara, Romania aut NATIONALLICENCE 700 1- Ribatti Domenico Department of Human Anatomy and Histology, School of Medicine, University of Bari Medical School, Piazza G. Cesare, 11 Policlinico, 70124, Bari, Italy aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/4(2011-12-01), 251-254 1591-8890 11:4<251 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer