caa a22 4500 445354852 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10238-010-0116-3 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0116-3 High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway [Elektronische Daten] [Hui-Fang Guo, Shu-Xia Liu, Yu-Jun Zhang, Qing-Juan Liu, Jun Hao, Li-Xia Gao] Recently, it was discovered that high mobility group box chromosomal protein 1 (HMGB1) acts as a potent pro-inflammatory cytokine that is released into the extracellular milieu. Signal transducer and activator of transcription (STAT) proteins play an important role in cytokine signaling. Some investigators have reported preferential activation of STAT1, and others have reported preferential activation of STAT3 in response to endogenous interleukin-6 (IL-6) in patients with rheumatoid arthritis. Here, we show that expression of the HMGB1 protein is increased in the articular tissues of collagen-induced arthritis (CIA) rats, especially in cytoplasm and extracellular, following synoviocyte proliferation and STAT1 activation. In vitro, recombined human HMGB1 induced RSC-364 cell proliferation, activated STAT1 phosphorylation, increased the expression of cyclin D1 and CDK4 protein, and decreased the expression of p21 protein. In summary, our study suggests that HMGB1 plays an important role of cytokine in the pathogenesis of RA, which possibly induces synovial cell proliferation by activating the STAT1 signal pathway. Springer-Verlag, 2010 Rheumatoid arthritis nationallicence HMGB1 nationallicence STAT nationallicence Cell proliferation nationallicence Guo Hui-Fang Department of Rheumatology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, China aut Liu Shu-Xia Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut Zhang Yu-Jun Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut Liu Qing-Juan Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut Hao Jun Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut Gao Li-Xia Department of Rheumatology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, China aut Clinical and Experimental Medicine Springer Milan 11/2(2011-06-01), 65-74 1591-8890 11:2<65 2011 11 10238 https://doi.org/10.1007/s10238-010-0116-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0116-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guo Hui-Fang Department of Rheumatology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, China aut NATIONALLICENCE 700 1- Liu Shu-Xia Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut NATIONALLICENCE 700 1- Zhang Yu-Jun Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut NATIONALLICENCE 700 1- Liu Qing-Juan Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut NATIONALLICENCE 700 1- Hao Jun Department of Pathology, Hebei Medical University, 050017, Shijiazhuang, China aut NATIONALLICENCE 700 1- Gao Li-Xia Department of Rheumatology, The Second Hospital of Hebei Medical University, 050000, Shijiazhuang, China aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/2(2011-06-01), 65-74 1591-8890 11:2<65 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer