caa a22 4500 445354917 CHVBK 20180317142856.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10238-010-0108-3 doi (NATIONALLICENCE)springer-10.1007/s10238-010-0108-3 Role of serum adiponectin level in the development of liver cirrhosis in patients with hepatitis C virus [Elektronische Daten] [Hatem Latif, Heba Assal, Mohamed Mahmoud, Wafaa Rasheed] Adiponectin possesses anti-inflammatory and insulin-sensitizing properties. Little is known about the role of adiponectin in hepatitis-C-related liver disease. The aim of our study was to find a relationship between serum adiponectin levels and different grades of steatohepatitis in HCV-infected patients and to correlate it with the severity of liver disease. Sixty HCV-infected patients were divided into two groups according to the presence/absence of steatosis proofed by abdominal ultrasonography and liver biopsy was selected. We evaluated the biochemical parameters for all patients including: ALT, AST, total bilirubin, direct bilirubin, alkaline phosphatase, serum albumin, prothrombin time, CBC, lipid profile, fasting blood glucose, fasting insulin, and serum adiponectin; HOMA-IR was calculated as [fasting insulin (mIU/l)×fasting glucose (mmol/l)]/22.5. We found that adiponectin was significantly lower in HCV-infected patients with steatosis than in those without steatosis. BMI, fasting blood glucose and HOMA-IR were significantly higher in HCV-infected patients with steatosis than in those without steatosis. Furthermore, it was found that steatosis correlates directly with fibrosis index, BMI, HOMA-IR, fasting blood glucose and ALT. Serum adiponectin levels inversely correlates with the grade of steatosis, histological activity index and the stage of fibrosis. Springer-Verlag, 2010 Adeponectin nationallicence HCV nationallicence Liver cirrhosis nationallicence Steatohepatitis nationallicence Latif Hatem The Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt aut Assal Heba The Departments of Internal Medicine, National Research Center, Cairo, Egypt aut Mahmoud Mohamed The Departments of Internal Medicine, National Research Center, Cairo, Egypt aut Rasheed Wafaa Medical Biochemistry, National Research Center, Cairo, Egypt aut Clinical and Experimental Medicine Springer Milan 11/2(2011-06-01), 123-129 1591-8890 11:2<123 2011 11 10238 https://doi.org/10.1007/s10238-010-0108-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10238-010-0108-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Latif Hatem The Department of Internal Medicine, Faculty of Medicine, Ain-Shams University, Cairo, Egypt aut NATIONALLICENCE 700 1- Assal Heba The Departments of Internal Medicine, National Research Center, Cairo, Egypt aut NATIONALLICENCE 700 1- Mahmoud Mohamed The Departments of Internal Medicine, National Research Center, Cairo, Egypt aut NATIONALLICENCE 700 1- Rasheed Wafaa Medical Biochemistry, National Research Center, Cairo, Egypt aut NATIONALLICENCE 773 0- Clinical and Experimental Medicine Springer Milan 11/2(2011-06-01), 123-129 1591-8890 11:2<123 2011 11 10238 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer