caa a22 4500 445355204 CHVBK 20180317142857.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0335-0 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0335-0 Association between high-sensitivity C-reactive protein and risk of early idiopathic Parkinson's disease [Elektronische Daten] [In-Uk Song, Sung-Woo Chung, Joong-Seok Kim, Kwang-Soo Lee] Although neuroinflammation is known to play an important role in the pathogeneses of neurodegenerative diseases, few studies have been conducted on the association between Parkinson's disease (PD) and high-sensitivity C-reactive protein (hs-CRP), which is the most studied biomarker of systemic inflammation. Therefore, we conducted this study to determine the clinical correlates of hs-CRP levels in early PD patients by comparing findings with those of normal controls. Sixty-three drug-naïve patients with early PD and 117 healthy subjects were recruited, and hs-CRP level differences were investigated in these two groups. It was found that hs-CRP levels in the early PD group were higher than those of healthy controls. Furthermore, when compared with normal controls, the odds ratio for PD based on hs-CRP level cut-off of 0.5 was 2.094 (95% CI=1.017-4.311, P=0.045). In this study, our findings support the hypothesis that neuroinflammatory reactions play an important role in the pathogenesis of PD. Springer-Verlag, 2010 Neuroinflammation nationallicence High-sensitivity C-reactive protein nationallicence Biomarker nationallicence Parkinson's disease nationallicence Song In-Uk Department of Neurology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665-8, Bupeong 6 dong, Bupeong-gu, 403-720, Incheon, Korea aut Chung Sung-Woo Department of Neurology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665-8, Bupeong 6 dong, Bupeong-gu, 403-720, Incheon, Korea aut Kim Joong-Seok Department of Neurology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea aut Lee Kwang-Soo Department of Neurology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea aut Neurological Sciences Springer Milan 32/1(2011-02-01), 31-34 1590-1874 32:1<31 2011 32 10072 https://doi.org/10.1007/s10072-010-0335-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0335-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Song In-Uk Department of Neurology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665-8, Bupeong 6 dong, Bupeong-gu, 403-720, Incheon, Korea aut NATIONALLICENCE 700 1- Chung Sung-Woo Department of Neurology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, 665-8, Bupeong 6 dong, Bupeong-gu, 403-720, Incheon, Korea aut NATIONALLICENCE 700 1- Kim Joong-Seok Department of Neurology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kwang-Soo Department of Neurology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 31-34 1590-1874 32:1<31 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer