caa a22 4500 445355212 CHVBK 20180317142857.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0433-z doi (NATIONALLICENCE)springer-10.1007/s10072-010-0433-z BDNF Val66Met polymorphism and brain volumes in multiple sclerosis [Elektronische Daten] [D. Dinacci, A. Tessitore, A. Russo, M. De Bonis, L. Lavorgna, O. Picconi, R. Sacco, S. Bonavita, A. Gallo, G. Servillo, L. Marcuccio, M. Comerci, P. Galletti, B. Alfano, G. Tedeschi] Brain derived neurotrophic factor (BDNF) regulates several CNS physiological and pathological processes. To investigate in multiple sclerosis (MS) patients, the relationship between the Val66Met polymorphism of BDNF and clinical markers of disease activity and MRI markers of focal and diffuse brain pathologies. 45 MS patients and 34 healthy controls (HCs) were genotyped and subjected to clinical-MRI examination. Global white matter fraction (gWM-f), gray matter-f (GM-f), cerebrospinal fluid-f (CSF-f), and abnormal WM-f were measured. We studied 26 Val/Val and 19 Val/Met patients and 23 Val/Val and 11 Val/Met HCs. We found that Val/Val patients had lower GM-f and higher CSF-f than Val/Val HCs; such differences were not statistically significant comparing Val/Met patients to HCs. The regression analysis showed that both Val/Met genotype and relapse number were associated with lower CSF-f. Our data suggest that Met allele might be a protective factor against MS as it is associated to a lower brain atrophy. Springer-Verlag, 2010 Multiple sclerosis nationallicence BDNF polymorphism nationallicence Brain atrophy nationallicence MRI nationallicence Dinacci D. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Tessitore A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Russo A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut De Bonis M. Oncology Reference Center of Basilicata, IRCCS-CROB, Rionero in Vulture (PZ), Italy aut Lavorgna L. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Picconi O. Opera CRO Scientific Advisor Board, Genoa, Italy aut Sacco R. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Bonavita S. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Gallo A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Servillo G. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Marcuccio L. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Comerci M. Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy aut Galletti P. Department of Biochemistry and Biophysics "F.Cedrangolo”, Second University of Naples, Naples, Italy aut Alfano B. Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy aut Tedeschi G. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 117-123 1590-1874 32:1<117 2011 32 10072 https://doi.org/10.1007/s10072-010-0433-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0433-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dinacci D. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Tessitore A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Russo A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- De Bonis M. Oncology Reference Center of Basilicata, IRCCS-CROB, Rionero in Vulture (PZ), Italy aut NATIONALLICENCE 700 1- Lavorgna L. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Picconi O. Opera CRO Scientific Advisor Board, Genoa, Italy aut NATIONALLICENCE 700 1- Sacco R. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Bonavita S. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Gallo A. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Servillo G. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Marcuccio L. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Comerci M. Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy aut NATIONALLICENCE 700 1- Galletti P. Department of Biochemistry and Biophysics "F.Cedrangolo”, Second University of Naples, Naples, Italy aut NATIONALLICENCE 700 1- Alfano B. Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy aut NATIONALLICENCE 700 1- Tedeschi G. Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 117-123 1590-1874 32:1<117 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer