caa a22 4500 445355298 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0428-9 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0428-9 Serial nerve conduction studies in vitamin B12 deficiency-associated polyneuropathy [Elektronische Daten] [Chi-Ren Huang, Wen-Neng Chang, Nai-Wen Tsai, Cheng-Hsien Lu] This report is on a 22-year-old male vegetarian with acute polyneuropathy secondary to vitamin B12 deficiency. He presented with weakness and numbness of the distal limbs and absent deep tendon reflex in all four extremities. Nerve conduction study (NCS) showed an axonal type sensori-motor polyneuropathy. Serum biochemical studies revealed vitamin B12 level of 119pg/mL (reference range 185-710pg/mL), with elevated creatine kinase (CK) (719U/L) and homocysteine (Hcy) (24.04μmol/L) levels. Anti-parietal cell antibody test was positive. The patient received both oral and intramuscular injection of vitamin B12. The amplitude of the median and ulnar motor NCS increased 2.5months later, while muscle power of the ankle plantar flexion and dorsiflexion recovered after 3.5 and 5.5months, respectively. Follow-up NCS after 14.5months showed response in sural NCS, but not the peroneal NCS. Follow-up also showed decreased serum Hcy and CK to 9.6μmol/L and 198U/L, respectively, and increasing amplitude of response. Recovery sequence involved muscle power of the proximal muscles, hands, plantar flexion, and dorsiflexion of the feet, and followed by sensory conduction. Springer-Verlag, 2010 B12 deficiency nationallicence Polyneuropathy nationallicence Nerve conduction study nationallicence Huang Chi-Ren Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut Chang Wen-Neng Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut Tsai Nai-Wen Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut Lu Cheng-Hsien Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut Neurological Sciences Springer Milan 32/1(2011-02-01), 183-186 1590-1874 32:1<183 2011 32 10072 https://doi.org/10.1007/s10072-010-0428-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0428-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Chi-Ren Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Chang Wen-Neng Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Tsai Nai-Wen Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut NATIONALLICENCE 700 1- Lu Cheng-Hsien Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, No. 123, Tai-Pei Rd, Niao-Song Township, 833, Kaohsiung, Taiwan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 183-186 1590-1874 32:1<183 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer