caa a22 4500 445355301 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0415-1 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0415-1 Clock T3111C and Per2 C111G SNPs do not influence circadian rhythmicity in healthy Italian population [Elektronische Daten] [Anna Choub, Michelangelo Mancuso, Fabio Coppedè, Annalisa LoGerfo, Daniele Orsucci, Lucia Petrozzi, Elisa DiCoscio, Michelangelo Maestri, Anna Rocchi, Enrica Bonanni, Gabriele Siciliano, Luigi Murri] A possible relationship between human circadian rhythmicity and polymorphisms in clock genes have been documented. However, these data are controversial, and studies both corroborating and denying them have been reported. T3111C Clock polymorphism had been associated with the human evening preference, however, this association has not been confirmed. Moreover, C111G Per2 polymorphism has been associated with the "morning larks” chronotype in one study, not yet replicated. We have, therefore, performed this study to evaluate whether Per2 C111G and Clock T3111C polymorphisms might influence sleep circadian rhythmicity in a sample of 219 Italian volunteers. A possible interaction between these polymorphisms was also investigated. No differences in Per2 C111G and Clock T3111C allele and genotype frequencies were found, and none of the combined Clock T3111C-Per2 C11G genotypes resulted more frequent in one group compared to the others. Present results do not support a role of these polymorphisms in the circadian phenotypes. Springer-Verlag, 2010 Clock nationallicence Human circadian rhythmicity nationallicence Per2 nationallicence SNPs nationallicence Choub Anna Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Mancuso Michelangelo Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Coppedè Fabio Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut LoGerfo Annalisa Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Orsucci Daniele Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Petrozzi Lucia Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut DiCoscio Elisa Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Maestri Michelangelo Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Rocchi Anna Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Bonanni Enrica Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Siciliano Gabriele Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Murri Luigi Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 89-93 1590-1874 32:1<89 2011 32 10072 https://doi.org/10.1007/s10072-010-0415-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0415-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Choub Anna Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Mancuso Michelangelo Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Coppedè Fabio Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- LoGerfo Annalisa Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Orsucci Daniele Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Petrozzi Lucia Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- DiCoscio Elisa Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Maestri Michelangelo Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Rocchi Anna Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Bonanni Enrica Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Siciliano Gabriele Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 700 1- Murri Luigi Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126, Pisa, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 89-93 1590-1874 32:1<89 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer