caa a22 4500 44535531X CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0395-1 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0395-1 Pursuit ocular movements in multiple sclerosis: a video-based eye-tracking study [Elektronische Daten] [Lorenzo De Santi, Pietro Lanzafame, Barbara Spanò, Giangaetano D'Aleo, Alessia Bramanti, Placido Bramanti, Silvia Marino] Multiple sclerosis (MS) patients frequently develop some form of ocular motor dysfunction during the disease. In previous studies, ocular motor abnormalities were found to correlate with clinical disability and with impaired cognitive performance. The objective of this study was to assess the pursuit ocular movement (POM) frequency in relapsing-remitting (RR) and secondary progressive (SP) MS patients by using a vision-based non-intrusive eye tracker. POM frequency was significantly lower (p<0.001) in MS patients compared to normal controls. No differences between RR and SP-MS patients and no correlation between POM and expanded disability status scale (EDSS) score were found. This exploratory study suggests that our vision-based system is a new simple non-intrusive method showing impairment of POM values in MS patients, even in the absence of association with clinical disability (EDSS). Future works on larger cohorts of MS patients might validate this eye tracking in MS clinical practice. Springer-Verlag, 2010 Eye movements nationallicence Multiple sclerosis nationallicence Pursuit ocular movements nationallicence Video-based eye-tracking system nationallicence De Santi Lorenzo IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Lanzafame Pietro IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Spanò Barbara IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut D'Aleo Giangaetano IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Bramanti Alessia IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Bramanti Placido IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Marino Silvia IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 67-71 1590-1874 32:1<67 2011 32 10072 https://doi.org/10.1007/s10072-010-0395-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0395-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- De Santi Lorenzo IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- Lanzafame Pietro IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- Spanò Barbara IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- D'Aleo Giangaetano IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- Bramanti Alessia IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- Bramanti Placido IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 700 1- Marino Silvia IRCCS Centro Neurolesi, "Bonino-Pulejo”, Via Provinciale Palermo, contrada Casazza, 98124, Messina, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 67-71 1590-1874 32:1<67 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer