caa a22 4500 445355336 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0387-1 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0387-1 Structures and connections of enkephalin- and γ-aminobutyric acid-immunoreactive profiles in the gustatory region of the nucleus tractus solitarius: a light and electron microscopic study [Elektronische Daten] [Wei Huang, Ju-Xiang Chen, Yi-Ming Li, Yi-Cheng Lu, Xiao-Jun Wu] GABA and enkephalin (ENK) are principle inhibitory transmitters in the rostral portion of the nucleus tractus solitarius (rNTS) for regulating the gustatory information. Although the existence of GABA- and ENK-immunoreactive (ir) profiles in the rNTS has been demonstrated, there are no morphological data revealing the connections between them. In the present study, using immunofluorescent and electron microscopic methods, we examined their relationship in the rNTS of rat. Results showed the following: (1) dense ENK-ir fibers and terminals and GABA-ir cell bodies, fibers, and terminals were observed in the rNTS; (2) ENK-ir terminals mainly make symmetric synapses with GABA-ir and immunonegative somas and dendrites; (3) co-existence of ENK/GABA-ir axon terminals and convergence of ENK- and GABA-ir terminals on one immunonegative soma or dendrite can also be observed. These results suggest that ENK should inhibit directly or excite indirectly (by blocking the inhibition of the GABAergic neurons) the gustatory neurons in the rNTS. Springer-Verlag, 2010 Enkephalin nationallicence gamma-aminobutyric acid nationallicence Nucleus tractus solitarius nationallicence Taste nationallicence Rat nationallicence Huang Wei Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Chen Ju-Xiang Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Li Yi-Ming Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Lu Yi-Cheng Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Wu Xiao-Jun Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut Neurological Sciences Springer Milan 32/1(2011-02-01), 53-58 1590-1874 32:1<53 2011 32 10072 https://doi.org/10.1007/s10072-010-0387-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0387-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Wei Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Chen Ju-Xiang Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Li Yi-Ming Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Lu Yi-Cheng Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 700 1- Wu Xiao-Jun Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, 200003, Shanghai, China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 53-58 1590-1874 32:1<53 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer