caa a22 4500 445355344 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0411-5 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0411-5 Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study [Elektronische Daten] [Maria Esposito, Marco Carotenuto] Primary headaches (migraines and tension-types headaches) are very common in school-aged children. Ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, was considered as a promising pharmacological aid for the treatment of migraine in adult patients because of its modulation of the glutamatergic transmission in the CNS and on antiplatelet activating factor (PAF). The aim of study is to verify the effectiveness and safety of association of Ginkgolide B/Coenzyme Q10/Riboflavin/Magnesium complex for brief prophylaxis in a population of school-aged children with migraine. In our sample after 3months of treatment with association of Ginkgolide B/CoenzymeQ10/Riboflavin/Magnesium complex, the mean frequency per month of migraine was significantly decreased (9.71±4.33 vs. 4.53±3.96 attacks; p<0.001). Our findings suggest that in childhood headache management, the use of alternative treatments must be considered not to evoke a placebo effect, but as soft therapy without adverse reactions. Springer-Verlag, 2010 Childhood migraine nationallicence Vitaminic complexes nationallicence Natural therapy nationallicence Brief prophylaxis nationallicence Esposito Maria Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5 PAD XI A, 80131, Naples, Italy aut Carotenuto Marco Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5 PAD XI A, 80131, Naples, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 79-81 1590-1874 32:1<79 2011 32 10072 https://doi.org/10.1007/s10072-010-0411-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0411-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Esposito Maria Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5 PAD XI A, 80131, Naples, Italy aut NATIONALLICENCE 700 1- Carotenuto Marco Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5 PAD XI A, 80131, Naples, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 79-81 1590-1874 32:1<79 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer