caa a22 4500 445355360 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0431-1 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0431-1 Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema [Elektronische Daten] [Hironaka Igarashi, Vincent Huber, Mika Tsujita, Tsutomu Nakada] We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemia, as reflected by percentage of brain swelling volume (%BSV), 12.1±6.3% in the treated group, compared to (20.8±5.9%) in the control group (p<0.05), and in the size of cortical infarction as reflected by the percentage of hemispheric lesion volume (%HLV), 20.0±7.6% in the treated group, compared to 30.0±9.1% in the control group (p<0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia. The Author(s), 2010 Aquaporin 4 nationallicence Brain ischemia nationallicence Brain edema nationallicence Magnetic resonance imaging nationallicence Igarashi Hironaka Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut Huber Vincent Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut Tsujita Mika Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut Nakada Tsutomu Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut Neurological Sciences Springer Milan 32/1(2011-02-01), 113-116 1590-1874 32:1<113 2011 32 10072 https://doi.org/10.1007/s10072-010-0431-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0431-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Igarashi Hironaka Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut NATIONALLICENCE 700 1- Huber Vincent Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut NATIONALLICENCE 700 1- Tsujita Mika Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut NATIONALLICENCE 700 1- Nakada Tsutomu Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, 1 Asahimachi, Chuoh-ku, 951-8585, Niigata, Japan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 113-116 1590-1874 32:1<113 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer