caa a22 4500 445355387 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0393-3 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0393-3 Assessment of uric acid and lipid peroxidation in serum and urine after hypoxia-ischemia neonatal in rats [Elektronische Daten] [V. Pimentel, F. Pinheiro, M. Kaefer, R. Moresco, M. Moretto] The aim of this study was to evaluate urinary uric acid (UA) and lipid peroxidation levels, plasma myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, and serum UA in neonatal rats subjected to hypoxia-ischemia neonatal HI model. The relevance of the findings is the fact that urinary lipid peroxidation and UA levels were significantly higher in 8days in HI group when compared with the control, returning to baseline levels 60days after HI. Hence, being an indication of purinic degradation during these first days post-HI. Furthermore, the higher levels of malondialdehyde (MDA) in urine in this period may be related to inadequate scavenging abilities of the immature nervous system and being noninvasive it may suggest the use of urinary MDA measurement as a marker for lipid peroxidation after HI insult. In application terms, these findings can help develop therapeutic interventions as soon as 8days after HI. Springer-Verlag, 2010 Hypoxic ischemia neonatal nationallicence Uric acid nationallicence Myeloperoxidase nationallicence Urinary lipid peroxidation nationallicence Pimentel V. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Pinheiro F. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Kaefer M. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Moresco R. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Moretto M. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut Neurological Sciences Springer Milan 32/1(2011-02-01), 59-65 1590-1874 32:1<59 2011 32 10072 https://doi.org/10.1007/s10072-010-0393-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0393-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pimentel V. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Pinheiro F. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Kaefer M. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Moresco R. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 700 1- Moretto M. Postgraduate Program in Pharmaceutical Sciences, Health Science Centre, Federal University of Santa Maria (UFSM), 97105-900, Santa Maria, RS, Brazil aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 59-65 1590-1874 32:1<59 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer