caa a22 4500 445355395 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0386-2 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0386-2 Co-existence of Parkinson's disease and progressive supranuclear palsy: case report and a review of the literature [Elektronische Daten] [Kumar Abhinav, Laura Marsh, Barbara Crain, Stephen Reich, Kevin Biglan] Idiopathic Parkinson's disease (PD) and progressive supranuclear palsy (PSP) are distinct clinicopathological entities characterized by α-synuclein and tau pathology, respectively. They have occasionally been reported to co-exist in the same patient. We describe a rare case of a 73-year-old Caucasian woman diagnosed as idiopathic PD 5years before her death yet at autopsy had not only PD, but also PSP. Although this patient fulfilled clinical criteria for idiopathic PD and did not have supranuclear ophthalmoplegia, she had several atypical features, including early postural instability with falls, early dysphagia, and a relatively rapid course. In conclusion, this case and a literature review highlight the co-existence of synuclein and tau pathology in the same patient and demonstrate that multiple diagnoses may exist in patients presenting with parkinsonism. The clinical heterogeneity seen in parkinsonism may reflect the occurrence of combined pathology. Springer-Verlag, 2010 Parkinson's disease (PD) nationallicence Progressive supranuclear palsy (PSP) nationallicence Parkinsonism nationallicence Neuropathology nationallicence Abhinav Kumar Department of Neurosurgery, Frenchay Hospital, Bristol, UK aut Marsh Laura Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Crain Barbara Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Reich Stephen Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA aut Biglan Kevin Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut Neurological Sciences Springer Milan 32/1(2011-02-01), 159-163 1590-1874 32:1<159 2011 32 10072 https://doi.org/10.1007/s10072-010-0386-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0386-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abhinav Kumar Department of Neurosurgery, Frenchay Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Marsh Laura Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Crain Barbara Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Reich Stephen Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Biglan Kevin Department of Neurology and Neurological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 159-163 1590-1874 32:1<159 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer