caa a22 4500 44535545X CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0439-6 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0439-6 Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review [Elektronische Daten] [Maria Giordana, Patrizia Ferrero, Silvia Grifoni, Alessia Pellerino, Andrea Naldi, Anna Montuschi] Amyotrophic lateral sclerosis (ALS) is generally considered to be a paradigm of pure motor neuron disorder; nevertheless, the possible occurrence of cognitive impairment up to a frank dementia in patients affected by ALS is recognized. The appraisal of the cognitive impairment in ALS patients is crucial not only to the therapeutic trials of this incurable disease, but also to the planning of care, compliance to interventions, the end-of-life decisions. The cognitive/behavioral changes of ALS patients are consistent with frontotemporal dysfunctions; the overlap of neuropathological features of ALS and frontotemporal lobe degeneration (FTLD) supports, in addition, the putative spectrum of ALS and FTD. In the present review, the pertinent clinical, genetic, neuropathological, neuropsychological and neuroimaging data of the literature are comprehensively and critically discussed. The distinct and overlapping features of ALS and FTD are pointed out, as well as the undisclosed questions deserving additional studies. Springer-Verlag, 2010 ALS nationallicence FTD nationallicence Dementia nationallicence Neuropathology nationallicence TDP-43 nationallicence Genetics nationallicence Neuropsychological evaluation nationallicence Giordana Maria Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Ferrero Patrizia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Grifoni Silvia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Pellerino Alessia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Naldi Andrea Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Montuschi Anna Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 9-16 1590-1874 32:1<9 2011 32 10072 https://doi.org/10.1007/s10072-010-0439-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0439-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Giordana Maria Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Ferrero Patrizia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Grifoni Silvia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Pellerino Alessia Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Naldi Andrea Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 700 1- Montuschi Anna Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 9-16 1590-1874 32:1<9 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer