caa a22 4500 445355522 CHVBK 20180317142858.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0412-4 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0412-4 The effect of natalizumab on cognitive function in patients with relapsing-remitting multiple sclerosis: preliminary results of a 1-year follow-up study [Elektronische Daten] [Flavia Mattioli, C. Stampatori, R. Capra] The objective of the study was to assess the natalizumab effect on the course of cognitive impairment in patients with relapsing-remitting multiple sclerosis (MS). Patients with active relapsing-remitting MS (n=17) were treated with natalizumab for 1year. The quasi control group included patients (n=7) with clinically stable MS. Assessment of disease course [expanded disability status scale (EDSS); number of relapses] and neuropsychological impairment [Wisconsin card sorting test (WCST); controlled oral word associations; verbal/non-verbal memory tests; paced auditory serial addition test] was conducted at baseline and after 1year. Natalizumab-treated patients experienced significantly fewer relapses compared with the previous year (P<0.05). At 1-year follow-up, EDSS score was unchanged and neuropsychological assessments of memory/executive functions showed a significant improvement in natalizumab-treated patients (all P<0.05). No changes were observed in the quasi control group. This preliminary study suggests that natalizumab could be effective in ameliorating cognitive functions in patients with active relapsing-remitting MS, over 1-year follow-up. Springer-Verlag, 2010 Multiple sclerosis nationallicence Natalizumab nationallicence Cognitive function nationallicence Relapsing-remitting nationallicence Mattioli Flavia Clinical Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut Stampatori C. Clinical Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut Capra R. Multiple Sclerosis Centre, Spedali Civili of Brescia, Brescia, Italy aut Neurological Sciences Springer Milan 32/1(2011-02-01), 83-88 1590-1874 32:1<83 2011 32 10072 https://doi.org/10.1007/s10072-010-0412-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0412-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mattioli Flavia Clinical Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Stampatori C. Clinical Neuropsychology Unit, Spedali Civili of Brescia, Via Nikolajewka, 13, 25123, Brescia, Italy aut NATIONALLICENCE 700 1- Capra R. Multiple Sclerosis Centre, Spedali Civili of Brescia, Brescia, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 83-88 1590-1874 32:1<83 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer