caa a22 4500 445355549 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10072-010-0424-0 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0424-0 Role of glial cells in neurotoxin-induced animal models of Parkinson's disease [Elektronische Daten] [Hironori Yokoyama, Hiroto Uchida, Hayato Kuroiwa, Jiro Kasahara, Tsutomu Araki] Dopaminergic neurons are selectively vulnerable to oxidative stress and inflammatory attack. The neuronal cell loss in the substantia nigra is associated with a glial response composed markedly of activated microglia and, to a lesser extent, of reactive astrocytes although these glial responses may be the source of neurotrophic factors and can protect against oxidative stress such as reactive oxygen species and reactive nitrogen species. However, the glial response can also mediate a variety of deleterious events related to the production of pro-inflammatory, pro-oxidant reactive species, prostaglandins, cytokines, and so on. In this review, we discuss the possible protective and deleterious effects of glial cells in the neurodegenerative diseases and examine how these factors may contribute to the pathogenesis of Parkinson's disease. This review suggests that further investigation concerning glial reaction in Parkinson's disease may lead to disease-modifying therapeutic approaches and may contribute to the pathogenesis of this disease. Springer-Verlag, 2010 Parkinson's disease nationallicence Glia nationallicence Oxidative stress nationallicence Inflammation nationallicence Cytokines nationallicence Neurotrophic factors nationallicence Neurodegeneration nationallicence Yokoyama Hironori Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut Uchida Hiroto Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut Kuroiwa Hayato Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut Kasahara Jiro Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut Araki Tsutomu Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut Neurological Sciences Springer Milan 32/1(2011-02-01), 1-7 1590-1874 32:1<1 2011 32 10072 https://doi.org/10.1007/s10072-010-0424-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0424-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yokoyama Hironori Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut NATIONALLICENCE 700 1- Uchida Hiroto Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut NATIONALLICENCE 700 1- Kuroiwa Hayato Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut NATIONALLICENCE 700 1- Kasahara Jiro Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut NATIONALLICENCE 700 1- Araki Tsutomu Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, 1-78, Sho-machi, 770-8505, Tokushima, Japan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/1(2011-02-01), 1-7 1590-1874 32:1<1 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer