caa a22 4500 445355573 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0625-1 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0625-1 Slowly progressive aphemia: a neuropsychological, conventional, and functional MRI study [Elektronische Daten] [R. Gallassi, L. Sambati, R. Poda, F. Oppi, M. Stanzani Maserati, D. Cevolani, R. Agati, R. Lodi] Slowly progressive aphemia (SPA) is a rare focal degenerative disorder characterized by severe dysarthria, frequent orofacial apraxia, dysprosody, phonetic and phonemic errors without global cognitive deterioration for many years. This condition is caused by a degeneration of anterior frontal lobe regions, mainly of the left frontal operculum. We report a case of SPA with a course of 8years, evaluated by repeated neuropsychological, conventional, and functional MRI examinations. In our case, neuropsychological examinations showed a progressive impairment of speech articulation including dysprosody, phonetic and phonemic errors, and slight writing errors. No global cognitive deterioration was detected and the patient is still completely autonomous. Morphological and functional investigations showed, respectively, a progressive atrophy and progressive impairment of the left frontal region, confirming the role of the opercular region in determining this rare syndrome. During verbal task generation as the cortical activation of this region gradually decreased, the language articulation worsened. Springer-Verlag, 2011 Aphemia nationallicence Dysarthria nationallicence Primary motor aphasia nationallicence Frontotemporal dementia nationallicence Apraxia of speech nationallicence Gallassi R. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Sambati L. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Poda R. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Oppi F. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Stanzani Maserati M. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Cevolani D. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut Agati R. Neuroradiological Unit, Bellaria Hospital, Bologna, Italy aut Lodi R. MR Spectroscopy Unit, Department of Internal Medicine, Aging, and Nephrology, University of Bologna, Bologna, Italy aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1179-1186 1590-1874 32:6<1179 2011 32 10072 https://doi.org/10.1007/s10072-011-0625-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0625-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallassi R. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Sambati L. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Poda R. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Oppi F. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Stanzani Maserati M. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Cevolani D. Department of Neurological Sciences, University of Bologna, via U. Foscolo 7, 40123, Bologna, Italy aut NATIONALLICENCE 700 1- Agati R. Neuroradiological Unit, Bellaria Hospital, Bologna, Italy aut NATIONALLICENCE 700 1- Lodi R. MR Spectroscopy Unit, Department of Internal Medicine, Aging, and Nephrology, University of Bologna, Bologna, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1179-1186 1590-1874 32:6<1179 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer