caa a22 4500 44535562X CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0728-8 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0728-8 Marburg's disease: a diagnostic dilemma [Elektronische Daten] [Kirti Gupta, Rakesh Vasishta, Param Kharbanda, Sameer Vyas, Sudesh Prabhakar] This report describes the clinical, radiological and autopsy findings of a young male suffering from acute, monophasic demyelinating disease presenting with acute onset of altered sensorium and a short past history of progressive multiple neurological deficits. The radiological findings revealed acute infarcts in the territory of anterior cerebral artery. The antemortem diagnosis centred on an infective (tubercular) aetiology leading to demyelination based on presence of tubercle bacilli in bronchoalveolar lavage (BAL) fluid. The autopsy revealed multiple subacute and acute plaques showing demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation, thereby confirming the diagnosis of Marburg's type of multiple sclerosis. Marburg's type is a fulminant demyelinating disorder characterised by a severe, rapidly evolving clinical course. Death occurs due to brain stem involvement or severe widespread cerebral lesions. Springer-Verlag, 2011 Multiple sclerosis nationallicence Marburg's type nationallicence Autopsy nationallicence Gupta Kirti Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India aut Vasishta Rakesh Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India aut Kharbanda Param Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut Vyas Sameer Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut Prabhakar Sudesh Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1195-1201 1590-1874 32:6<1195 2011 32 10072 https://doi.org/10.1007/s10072-011-0728-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0728-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gupta Kirti Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Vasishta Rakesh Department of Histopathology, Post Graduate Institute of Medical Education and Research (PGIMER), 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Kharbanda Param Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut NATIONALLICENCE 700 1- Vyas Sameer Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut NATIONALLICENCE 700 1- Prabhakar Sudesh Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1195-1201 1590-1874 32:6<1195 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer