caa a22 4500 445355646 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0602-8 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0602-8 Cognitive impairment and event-related potentials in paediatric multiple sclerosis: 2-year study [Elektronische Daten] [S. Lori, E. Portaccio, V. Zipoli, M. Giannini, S. Scarpelli, B. Goretti, M. Amato] Approximately, 3-10% of patients with multiple sclerosis (MS) present a disease onset before the age of 18years. Although growing attention is dedicated to cognitive impairment and its functional consequences in paediatric MS, so far no study has explored possible neurophysiologic correlates. The study's aim was to describe event-related potentials in relationship with cognitive performance in children and adolescents with MS compared with demographically matched healthy controls (HC), providing two-year follow-up data. Six MS subjects aged between 9 and 17years were assessed through an extensive neuropsychological battery at two time points. Event-related potentials with an odd-ball acoustic paradigm were also recorded in the patients and in nine HC. At baseline, four out of six patients failed three or more cognitive tasks and were classified as cognitively impaired. In all the cognitively impaired patients, we found abnormal latencies and amplitudes of the P300. After 2years, five patients exhibited a deteriorating cognitive performance and a corresponding deterioration of the P300 parameters. In our group of children and adolescents with MS, changes in P300 parameters proceeded in parallel with deteriorating cognitive performance. P300 might represent an objective parameter to monitor cognitive changes in paediatric MS. Springer-Verlag, 2011 Paediatric multiple sclerosis nationallicence Cognitive impairment nationallicence Event-related potentials nationallicence Lori S. Department of Neurophysiopathology, Careggi Hospital, Florence, Italy aut Portaccio E. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Zipoli V. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Giannini M. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Scarpelli S. Department of Neurophysiopathology, Careggi Hospital, Florence, Italy aut Goretti B. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Amato M. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1043-1046 1590-1874 32:6<1043 2011 32 10072 https://doi.org/10.1007/s10072-011-0602-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0602-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lori S. Department of Neurophysiopathology, Careggi Hospital, Florence, Italy aut NATIONALLICENCE 700 1- Portaccio E. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Zipoli V. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Giannini M. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Scarpelli S. Department of Neurophysiopathology, Careggi Hospital, Florence, Italy aut NATIONALLICENCE 700 1- Goretti B. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 700 1- Amato M. Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1043-1046 1590-1874 32:6<1043 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer