caa a22 4500 445355670 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0632-2 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0632-2 Microglial activation during acute cerebral infarction in the presence of diabetes mellitus [Elektronische Daten] [Gang Li, Xiaoyun Xu, Desheng Wang, Junchen Wang, Yue Wang, Jinming Yu] The patients suffering from acute cerebral infarction in the presence of diabetes mellitus (DMCI) often have poor clinical outcomes when compared with those in the absence of diabetes mellitus (non-DMCI), but the corresponding differences in pathology still remain elusive. Here, we investigated the proliferation of microglia in DMCI and non-DMCI. Patients who came to autopsy involved four DMCI cases and four non-DMCI cases. The peri-infarct region and the equivalent non-lesional region in the contralateral hemisphere were removed and analyzed. The hematoxylin-eosin staining and immunohistochemistry staining with anti-ferritin were used for evaluating the microglial activation. We found a more evident microglial proliferation in the peri-infarct region (P<0.01) and in the non-lesional hemisphere (P<0.05) in DMCI than in non-DMCI patients. In addition, neuronophagia was observed in peri-infarct region of DMCI. Future studies are warranted to further clarify the influence of microglial activation in DMCI. Springer-Verlag, 2011 Diabetes mellitus nationallicence Cerebral infarction nationallicence Microglia nationallicence Li Gang Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut Xu Xiaoyun Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut Wang Desheng Department of Neurology, First Hospital of Harbin Medical University, 150001, Harbin, China aut Wang Junchen Department of Pathology, East Hospital, Tongji University, 200120, Shanghai, China aut Wang Yue Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut Yu Jinming Department of Preventive Medicine, Medical College, Tongji University, 200092, Shanghai, China aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1075-1079 1590-1874 32:6<1075 2011 32 10072 https://doi.org/10.1007/s10072-011-0632-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0632-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Gang Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut NATIONALLICENCE 700 1- Xu Xiaoyun Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut NATIONALLICENCE 700 1- Wang Desheng Department of Neurology, First Hospital of Harbin Medical University, 150001, Harbin, China aut NATIONALLICENCE 700 1- Wang Junchen Department of Pathology, East Hospital, Tongji University, 200120, Shanghai, China aut NATIONALLICENCE 700 1- Wang Yue Department of Neurology, East Hospital, Tongji University, Jimo Road, No. 150, 200210, Shanghai, China aut NATIONALLICENCE 700 1- Yu Jinming Department of Preventive Medicine, Medical College, Tongji University, 200092, Shanghai, China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1075-1079 1590-1874 32:6<1075 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer