caa a22 4500 445355700 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0748-4 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0748-4 The effects of aging and Alzheimer's disease on associative recognition memory [Elektronische Daten] [Risa Hanaki, Nobuhito Abe, Toshikatsu Fujii, Aya Ueno, Yoshiyuki Nishio, Kotaro Hiraoka, Tatsuo Shimomura, Osamu Iizuka, Mayumi Shinohara, Kazumi Hirayama, Etsuro Mori] We investigated the effects of aging and Alzheimer's disease (AD) on item and associative recognition memory. Three groups of participants (younger adults, elderly adults, and AD patients) studied photographs of common objects that were located on either the left or the right side of a black computer screen inside either a red or a blue square. In a subsequent old/new recognition memory test, the participants were presented with four kinds of stimuli: "intact” stimuli, which were presented as they were during the study phase; "location-altered” stimuli, which were presented in a different location; "color-altered” stimuli, which were presented with a different surrounding color; and "new” stimuli, which consisted of photographs that had not been presented during the study phase. Compared with younger adults, the older adults showed equivalent performance in simple item recognition but worse performance in discriminating location-altered and color-altered stimuli. Compared with older adults, the AD patients showed equivalent performance in discriminating color-altered stimuli but worse performance in simple item recognition and the discrimination of location-altered stimuli. We speculate that distinct structural and functional changes in specific brain regions that are caused by aging and AD are responsible for the different patterns of memory impairment. Springer-Verlag, 2011 Aging nationallicence Alzheimer's disease nationallicence Associative recognition nationallicence Item recognition nationallicence Memory nationallicence Hanaki Risa Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Abe Nobuhito Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Fujii Toshikatsu Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Ueno Aya Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Nishio Yoshiyuki Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Hiraoka Kotaro Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Shimomura Tatsuo Department of Rehabilitation Medicine, Akita Prefectural Center of Rehabilitation and Psychiatric Medicine, Akita, Japan aut Iizuka Osamu Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Shinohara Mayumi Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Hirayama Kazumi Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Mori Etsuro Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1115-1122 1590-1874 32:6<1115 2011 32 10072 https://doi.org/10.1007/s10072-011-0748-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0748-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hanaki Risa Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Abe Nobuhito Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Fujii Toshikatsu Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Ueno Aya Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Nishio Yoshiyuki Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Hiraoka Kotaro Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Shimomura Tatsuo Department of Rehabilitation Medicine, Akita Prefectural Center of Rehabilitation and Psychiatric Medicine, Akita, Japan aut NATIONALLICENCE 700 1- Iizuka Osamu Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Shinohara Mayumi Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Hirayama Kazumi Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Mori Etsuro Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1115-1122 1590-1874 32:6<1115 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer