caa a22 4500 445355719 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0761-7 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0761-7 Pharmacological and behavioral characterization of the saphenous chronic constriction injury model of neuropathic pain in rats [Elektronische Daten] [Ozgur Gunduz, Cagatay Oltulu, Rabia Guven, Dilek Buldum, Ahmet Ulugol] The aim of the present study was to develop a new experimental pain model by adapting the chronic constriction injury (CCI) model of the sciatic nerve to the exclusively sensory saphenous nerve in rats. Animals were divided into naïve, sham, and two experimental groups, in which two or four 4-0 chromic gut ligatures were loosely ligated around the saphenous nerve. Then, behavioral signs of neuropathic pain were observed for 8weeks. In rats with four ligatures, prominent mechanical allodynia and thermal hyperalgesia developed; these behavioral signs were not prominent in rats with two ligatures. Pharmacological analysis was made in rats with four loose ligations; morphine and WIN 55,212-2, a cannabinoid agonist, reversed all of the modalities tested, whereas gabapentin only suppressed mechanical allodynia and amitriptyline only reduced mechanical hyperalgesia. Our data establish a rat model of saphenous CCI with significant allodynia and hyperalgesia, which is sensitive to a number of analgesic compounds. Springer-Verlag, 2011 Neuropathic pain nationallicence Allodynia nationallicence Hyperalgesia nationallicence Animal model nationallicence Saphenous nerve nationallicence Gunduz Ozgur Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut Oltulu Cagatay Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut Guven Rabia Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut Buldum Dilek Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut Ulugol Ahmet Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1135-1142 1590-1874 32:6<1135 2011 32 10072 https://doi.org/10.1007/s10072-011-0761-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0761-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gunduz Ozgur Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut NATIONALLICENCE 700 1- Oltulu Cagatay Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut NATIONALLICENCE 700 1- Guven Rabia Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut NATIONALLICENCE 700 1- Buldum Dilek Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut NATIONALLICENCE 700 1- Ulugol Ahmet Department of Pharmacology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1135-1142 1590-1874 32:6<1135 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer