caa a22 4500 445355735 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0598-0 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0598-0 Bickerstaff's brainstem encephalitis: case report and Tc99m brain SPECT findings [Elektronische Daten] [P. Nicolao, M. Zoccarato, M. Dalsasso, P. Zucchetta, R. Padoan, F. Michielan, B. Tavolato] A 21-year-old healthy female suffered from an upper respiratory tract infection and 2days later developed diplopia, unsteady gait, dysarthria and a profound disturbance of consciousness with rapid development of coma. Brain MRI and Tc99m brain perfusion SPECT, EEG, neurophysiological tests and CSF analysis results were unspecific. The detection of serum anti-GQ1b IgG autoantibodies at high titre led to the diagnosis of Bickerstaff's brainstem encephalitis (BBE). Clinical symptoms resolved after treatment with plasma exchange and the outcome was good. Brain MRI was normal, and Tc99m brain perfusion SPECT demonstrated hypoperfusion of the whole cerebral hemispheres and basal ganglia with relative sparing of the thalami and the brainstem. Similar to brain MRI, the sensitivity of Tc99m brain perfusion SPECT in detecting brainstem lesions in typical BBE patients seems to be low. Springer-Verlag, 2011 SPECT nationallicence Bickerstaff nationallicence Anti-GQ1b nationallicence Nicolao P. Service of Neurology, S. Maria del Prato Hospital, Feltre, Italy aut Zoccarato M. Department of Neurosciences, University of Padua, Padua, Italy aut Dalsasso M. Department of Pharmacology and Anesthesiology, University of Padua, Padua, Italy aut Zucchetta P. Nuclear Medicine Service, University Hospital of Padua, Padua, Italy aut Padoan R. Service of Neurology, S. Maria del Prato Hospital, Feltre, Italy aut Michielan F. Department of Pharmacology and Anesthesiology, University of Padua, Padua, Italy aut Tavolato B. Department of Neurosciences, University of Padua, Padua, Italy aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1153-1156 1590-1874 32:6<1153 2011 32 10072 https://doi.org/10.1007/s10072-011-0598-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0598-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicolao P. Service of Neurology, S. Maria del Prato Hospital, Feltre, Italy aut NATIONALLICENCE 700 1- Zoccarato M. Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Dalsasso M. Department of Pharmacology and Anesthesiology, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Zucchetta P. Nuclear Medicine Service, University Hospital of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Padoan R. Service of Neurology, S. Maria del Prato Hospital, Feltre, Italy aut NATIONALLICENCE 700 1- Michielan F. Department of Pharmacology and Anesthesiology, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Tavolato B. Department of Neurosciences, University of Padua, Padua, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1153-1156 1590-1874 32:6<1153 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer