caa a22 4500 445355751 CHVBK 20180317142859.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0578-4 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0578-4 The direct cost of patients with multiple sclerosis: a survey from Italian MS centres [Elektronische Daten] [Berto P, Amato MP, Bellantonio P, Bortolon F, Cavalla P, Florio C, Lugaresi A, Montanari E, Rottoli M, Simone IL, Zaffaroni M] Multiple sclerosis (MS) is a chronic progressive disease of the CNS causing disability and neurological symptoms that carry a substantial burden. Previous Italian studies appear outdated, and investigation on the burden of recently marketed drug treatments should provide further economic evidence for policy makers. The objective of the study was to investigate patterns of care, resource consumption and direct medical cost of MS, in the perspective of the public health-care provider. Ten MS experts from public centres extracted and reported data of all MS patients seen during 2009, using a detailed questionnaire. The data of 8,326 MS patients were analysed: the course was relapsing-remitting in 5,376 (62%), secondary progressive in 1,798 (23%) and primary progressive in 691 (9%); 461 (6%) had a clinically isolated syndrome. The EDSS score was 0-3.5 in 5,118 (61%) patients, 4-6.5 in 2,408 (29%) and 7-9.5 in 800 (10%). The average cost of diagnosis (N=694) was 1,236€/patient with large variations between centres due to the chosen diagnostic setting. The average direct medical cost for biological disease-modifying drugs (bio-DMD) was 10,444€/patient/year (cost/patient by primary drug: 9,501€ for interferon (IFN)-beta1a-im; 8,553€ for IFN-beta1b; 11,255€ for IFN-beta1a-sc44; 9,883€ for IFN-beta1a-sc22; 8,174€ for glatiramer acetate (GA); 21,817€ for natalizumab) and 3,151€ for non-bio-DMD. The cost of diagnosis is largely influenced by care setting, due to local health-care provision patterns. The annual medical cost/patient is largely driven by the cost of drugs (89.2% of total); GA represents the least expensive bio-DMD in the Italian health-care setting. Springer-Verlag, 2011 Multiple sclerosis nationallicence Cost nationallicence Italy nationallicence Disease-modifying biologics nationallicence P Berto PBE Consulting srl, Vicolo Stella 6, 37121, Verona, Italy aut MP Amato Department of Neurological and Psychiatric Sciences, Firenze University, Firenze, Italy aut P Bellantonio MS Center IRCCS Neuromed, Pozzilli, Italy aut F Bortolon Department of Neurology, MS Center, San Bortolo Hospital, Vicenza, Italy aut P Cavalla Department of Neurosciences, MS Center, Torino University, Torino, Italy aut C Florio Department of Neurology, Ospedale Cardarelli, Napoli, Italy aut A Lugaresi Department of Neuroscience and Imaging, MS Center, "G. d'Annunzio” University, Chieti, Italy aut E Montanari Department of Neurology, Ospedale Civile, Fidenza, Italy aut M Rottoli MS Center, Ospedali Riuniti, Bergamo, Italy aut IL Simone Department of Neurological and Psychological Sciences, Bari University, Bari, Italy aut M Zaffaroni MS Center, S. Antonio Abate Hospital, Gallarate, Italy aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1035-1041 1590-1874 32:6<1035 2011 32 10072 https://doi.org/10.1007/s10072-011-0578-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0578-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- P Berto PBE Consulting srl, Vicolo Stella 6, 37121, Verona, Italy aut NATIONALLICENCE 700 1- MP Amato Department of Neurological and Psychiatric Sciences, Firenze University, Firenze, Italy aut NATIONALLICENCE 700 1- P Bellantonio MS Center IRCCS Neuromed, Pozzilli, Italy aut NATIONALLICENCE 700 1- F Bortolon Department of Neurology, MS Center, San Bortolo Hospital, Vicenza, Italy aut NATIONALLICENCE 700 1- P Cavalla Department of Neurosciences, MS Center, Torino University, Torino, Italy aut NATIONALLICENCE 700 1- C Florio Department of Neurology, Ospedale Cardarelli, Napoli, Italy aut NATIONALLICENCE 700 1- A Lugaresi Department of Neuroscience and Imaging, MS Center, "G. d'Annunzio” University, Chieti, Italy aut NATIONALLICENCE 700 1- E Montanari Department of Neurology, Ospedale Civile, Fidenza, Italy aut NATIONALLICENCE 700 1- M Rottoli MS Center, Ospedali Riuniti, Bergamo, Italy aut NATIONALLICENCE 700 1- IL Simone Department of Neurological and Psychological Sciences, Bari University, Bari, Italy aut NATIONALLICENCE 700 1- M Zaffaroni MS Center, S. Antonio Abate Hospital, Gallarate, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1035-1041 1590-1874 32:6<1035 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer