caa a22 4500 445355840 CHVBK 20180317142900.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0678-1 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0678-1 Cardiovascular safety of aripiprazole and pimozide in young patients with Tourette syndrome [Elektronische Daten] [Mariangela Gulisano, Paola Calì, Andrea Cavanna, Clare Eddy, Hugh Rickards, Renata Rizzo] The pharmacotherapy for tic management in Tourette syndrome (TS) relies on neuroleptics, which have been associated with electrocardiographic abnormalities, including QTc interval prolongation. This study assessed the cardiovascular safety of the newer antipsychotic aripiprazole in comparison with the neuroleptic pimozide among young patients affected by TS. Fifty patients aged 6-18years were assigned to either pimozide (n=25; mean daily dose 4.4mg/die) or aripiprazole (n=25; 5.3mg/die) treatment for up to 24months. All patients underwent five serial cardiovascular assessments (baseline, 6, 12, 18 and 24months). The group treated with pimozide showed significant changes in blood pressure (decreased), QT and QTc (both prolonged). The aripiprazole group showed changes from baseline to peak values in blood pressure (increased), whilst modifications in QT and QTc were not statistically significant. At equivalent doses, aripiprazole is characterised by a safer cardiovascular profile than pimozide, being associated with a lower frequency of QTc prolongation. Springer-Verlag, 2011 Tourette syndrome nationallicence Aripiprazole nationallicence Pimozide nationallicence Electrocardiogram nationallicence QTc interval nationallicence Gulisano Mariangela Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut Calì Paola Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut Cavanna Andrea Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut Eddy Clare Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut Rickards Hugh Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut Rizzo Renata Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1213-1217 1590-1874 32:6<1213 2011 32 10072 https://doi.org/10.1007/s10072-011-0678-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0678-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gulisano Mariangela Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut NATIONALLICENCE 700 1- Calì Paola Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut NATIONALLICENCE 700 1- Cavanna Andrea Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut NATIONALLICENCE 700 1- Eddy Clare Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut NATIONALLICENCE 700 1- Rickards Hugh Department of Neuropsychiatry, University of Birmingham Birmingham and Solihull Mental Health NHS Foundation Trust, Barberry Building, B152FG, Birmingham, UK aut NATIONALLICENCE 700 1- Rizzo Renata Section of Child Neurology, Department of Pediatrics, Catania University, Catania, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1213-1217 1590-1874 32:6<1213 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer