caa a22 4500 44535593X CHVBK 20180317142900.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0600-x doi (NATIONALLICENCE)springer-10.1007/s10072-011-0600-x Head tremor secondary to MS resolved with rituximab [Elektronische Daten] [Chakorn Chansakul, Guillermo Moguel-Cobos, Roberto Bomprezzi] We describe the case of a 33-year-old woman who presented with a 2-month history of worsening head tremor. The medical evaluation led to the new diagnosis of MS and the MRI of brain demonstrated prominently active disease. Intravenous rituximab was started according to the HERMES trial, and significant improvement was noted. She has received additional rituximab dosing approximately every 6months, and at the 2-year follow-up the tremor has not recurred. The resolution of head tremor likely resulted from the complete suppression of MS disease activity, which must have allowed restoration of normal neural circuitry. In agreement with a growing body of evidence that supports early control of MS disease activity to prevent accumulation of fixed disability, this case advocates for aggressive immunological therapy at the onset of tremor in MS patients. Springer-Verlag, 2011 Multiple sclerosis nationallicence Cerebellar tremor nationallicence Head tremor nationallicence Rituximab nationallicence Chansakul Chakorn Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut Moguel-Cobos Guillermo Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut Bomprezzi Roberto Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1157-1160 1590-1874 32:6<1157 2011 32 10072 https://doi.org/10.1007/s10072-011-0600-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0600-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chansakul Chakorn Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Moguel-Cobos Guillermo Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut NATIONALLICENCE 700 1- Bomprezzi Roberto Division of Neurology, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, 500 West Thomas Road, Suite 300, 85013, Phoenix, AZ, USA aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1157-1160 1590-1874 32:6<1157 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer