caa a22 4500 445355972 CHVBK 20180317142900.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10072-011-0601-9 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0601-9 Central pontine myelinolysis presented after prophylactic cranial irradiation in small cell lung cancer [Elektronische Daten] [Yoon-Sik Jo, Sang-Don Han, Sang-Jun Na] Prophylactic cranial irradiation (PCI) should now be considered as a part of the standard treatment of patients with small cell lung cancer (SCLC) in complete remission. The PCI has been offered in SCLC to reduce the incidence of brain metastasis and increase survival. The complications of PCI were reported brain necrosis, seizure or dementia. The complications were more frequent when chemotherapy was given at the time of cranial irradiation, or large radiation fraction size was employed. It is established that the pathophysiological reaction to irradiation in the normal brain tissue is necrosis, demyelinization, and diffuse changes due to wall thickening of the vascular structures. However, central pontine myelinolysis (CPM) of low dose irradiation like PCI is very rare. We report a patient with the classical syndrome of CPM following PCI for SCLC. The diagnosis was supported by typical features on magnetic resonance imaging. Springer-Verlag, 2011 Prophylactic cranial irradiation nationallicence Small cell lung cancer nationallicence Central pontine myelinolysis nationallicence Jo Yoon-Sik Department of Neurology, School of Medicine, Konkuk University, Chungju Hospital, Chungju, Republic of Korea aut Han Sang-Don Department of Neurology, School of Medicine, Konkuk University, Chungju Hospital, Chungju, Republic of Korea aut Na Sang-Jun Department of Neurology, Konyang University College of Medicine, Konyang University Hospital, 685 Gasuwon-dong, Seo-gu, Daejeon, Republic of Korea aut Neurological Sciences Springer Milan 32/6(2011-12-01), 1161-1163 1590-1874 32:6<1161 2011 32 10072 https://doi.org/10.1007/s10072-011-0601-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0601-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jo Yoon-Sik Department of Neurology, School of Medicine, Konkuk University, Chungju Hospital, Chungju, Republic of Korea aut NATIONALLICENCE 700 1- Han Sang-Don Department of Neurology, School of Medicine, Konkuk University, Chungju Hospital, Chungju, Republic of Korea aut NATIONALLICENCE 700 1- Na Sang-Jun Department of Neurology, Konyang University College of Medicine, Konyang University Hospital, 685 Gasuwon-dong, Seo-gu, Daejeon, Republic of Korea aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/6(2011-12-01), 1161-1163 1590-1874 32:6<1161 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer