caa a22 4500 445356030 CHVBK 20180317142900.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10072-011-0504-9 doi (NATIONALLICENCE)springer-10.1007/s10072-011-0504-9 Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson's disease in Southern Italy [Elektronische Daten] [Valentina Greco, Elvira De Marco, Francesca Rocca, Ferdinanda Annesi, Donatella Civitelli, Giovanni Provenzano, Patrizia Tarantino, Vittorio Scornaienchi, Franco Pucci, Maria Salsone, Fabiana Novellino, Maurizio Morelli, Sandra Paglionico, Antonio Gambardella, Aldo Quattrone, Grazia Annesi] Iron overload may lead to neurodegenerative disorders such as Parkinson's disease (PD) and alterations of iron-related genes might be involved in the pathogenesis of this disease. The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF). We examined four known polymorphisms, C282Y and H63D in the HFE gene, G258S in the TF gene and S82G in the TFR gene, in 181 sporadic PD patients and 180 controls from Southern Italy to investigate their possible role in susceptibility to PD. No significant differences were found in genotype and allele frequencies between PD and controls for all the polymorphisms studied, suggesting that these variants do not contribute significantly to the risk of PD. Springer-Verlag, 2011 Parkinson's disease nationallicence Iron nationallicence HFE gene nationallicence TF gene nationallicence TFR gene nationallicence Greco Valentina Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut De Marco Elvira Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Rocca Francesca Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Annesi Ferdinanda Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Civitelli Donatella Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Provenzano Giovanni Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Tarantino Patrizia Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Scornaienchi Vittorio Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Pucci Franco Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Salsone Maria Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Novellino Fabiana Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Morelli Maurizio Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Paglionico Sandra Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Gambardella Antonio Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Quattrone Aldo Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut Annesi Grazia Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut Neurological Sciences Springer Milan 32/3(2011-06-01), 525-527 1590-1874 32:3<525 2011 32 10072 https://doi.org/10.1007/s10072-011-0504-9 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0504-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Greco Valentina Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- De Marco Elvira Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Rocca Francesca Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Annesi Ferdinanda Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Civitelli Donatella Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Provenzano Giovanni Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Tarantino Patrizia Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Scornaienchi Vittorio Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Pucci Franco Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Salsone Maria Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Novellino Fabiana Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Morelli Maurizio Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Paglionico Sandra Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Gambardella Antonio Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 700 1- Quattrone Aldo Institute of Neurology, University Magna Graecia, Catanzaro, Italy aut NATIONALLICENCE 700 1- Annesi Grazia Institute of Neurological Sciences, National Research Council, Contrada Burga, 87050, Mangone (Cosenza), Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/3(2011-06-01), 525-527 1590-1874 32:3<525 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer