caa a22 4500 445356073 CHVBK 20180317142900.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10072-010-0402-6 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0402-6 Electroacupuncture enhances cell proliferation and neuronal differentiation in young rat brains [Elektronische Daten] [Jianfeng Gao, Sheng Wang, Xiaoyang Wang, Changlian Zhu] To investigate the effect of electroacupuncture on cell proliferation and differentiation in young rat hippocampus, postnatal day-14 rats were assigned randomly to control, ketamine anesthesia, nonacupoint, or acupoint electroacupuncture groups. Electroacupuncture was applied at bilateral acupoints (Quchi, Waiguan, Huantiao, and Zusanli) 30min daily for 7 successive days. The proliferation and neuronal differentiation of proliferated surviving cells in the dentate gyrus were evaluated at 4weeks after last stimulation. The stimulatory effect of electroacupuncture on cell proliferation had a long-lasting effect, as indicated by the increased phosphor-histone H3-positive cells. The number of proliferated and survival cells, indicated by BrdU labeling, was highest in the electroacupuncture group. The number of newly differentiated neurons, as indicated by BrdU/NeuN double labeling, was significantly higher in the electroacupuncture group than in any of the other groups. This finding provides a theoretical basis for the clinical application of acupuncture to cerebral injury rehabilitation in children. Springer-Verlag, 2010 Cell proliferation nationallicence Electroacupuncture nationallicence Hippocampus nationallicence Neurogenesis nationallicence Gao Jianfeng Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut Wang Sheng Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut Wang Xiaoyang Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut Zhu Changlian Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut Neurological Sciences Springer Milan 32/3(2011-06-01), 369-374 1590-1874 32:3<369 2011 32 10072 https://doi.org/10.1007/s10072-010-0402-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0402-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gao Jianfeng Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut NATIONALLICENCE 700 1- Wang Sheng Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut NATIONALLICENCE 700 1- Wang Xiaoyang Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut NATIONALLICENCE 700 1- Zhu Changlian Department of Pediatrics, The Third Affiliated Hospital of Zhengzhou University, Kangfuqain Street 7, 450052, Zhengzhou, China aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/3(2011-06-01), 369-374 1590-1874 32:3<369 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer