caa a22 4500 445356081 CHVBK 20180317142900.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10072-010-0473-4 doi (NATIONALLICENCE)springer-10.1007/s10072-010-0473-4 Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience [Elektronische Daten] [Marcello Marchetti, Ida Milanesi, Chiara Falcone, Michela De Santis, Luisa Fumagalli, Lorenzo Brait, Livia Bianchi, Laura Fariselli] The treatment of brain metastases is changing. Many different radiotherapy options are now available and under clinical evaluation. As part of this effort, we retrospectively evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in patients with up to three brain metastases. Sixty-five patients with 81 lesions were treated with hypofractionated radiotherapy. Median dose was 24Gy in three fractions. Median follow-up was 24.6months. Actuarial tumour control was 75 and 45% at 9months and 24months after treatment, respectively. Median survival time was 7.5months, and 32% of the patients died from brain tumour progression. Actuarial overall survival was 75% at 3months and 25% at 12months. Recursive partitioning analysis class was the only significant prognostic factor. Neoadjuvant whole-brain radiotherapy (in 29 patients) had no impact on survival or local control. Neurological status improved in 42 patients (65%). Adverse events were rare and usually mild. This experience suggests HSRT should be considered as an alternative approach in the treatment of one to three metastatic lesions in selected patients. Springer-Verlag, 2011 Cerebral oligometastases nationallicence Hypofractionated stereotactic radiotherapy nationallicence Whole-brain radiotherapy nationallicence Marchetti Marcello Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut Milanesi Ida Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut Falcone Chiara Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut De Santis Michela Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut Fumagalli Luisa Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut Brait Lorenzo CyberKnife Center CDI, Milan, Italy aut Bianchi Livia CyberKnife Center CDI, Milan, Italy aut Fariselli Laura Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut Neurological Sciences Springer Milan 32/3(2011-06-01), 393-399 1590-1874 32:3<393 2011 32 10072 https://doi.org/10.1007/s10072-010-0473-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-010-0473-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marchetti Marcello Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Milanesi Ida Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Falcone Chiara Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- De Santis Michela Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Fumagalli Luisa Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 700 1- Brait Lorenzo CyberKnife Center CDI, Milan, Italy aut NATIONALLICENCE 700 1- Bianchi Livia CyberKnife Center CDI, Milan, Italy aut NATIONALLICENCE 700 1- Fariselli Laura Department of Neurosurgery, Division of Radiotherapy, Fondazione IRCCS Istituto Neurologico "C.Besta”, Via Celoria 11, 20133, Milan, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/3(2011-06-01), 393-399 1590-1874 32:3<393 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer