caa a22 4500 44535612X CHVBK 20180317142900.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10072-011-0546-z doi (NATIONALLICENCE)springer-10.1007/s10072-011-0546-z Serotonin toxicity: a short review of the literature and two case reports involving Citalopram [Elektronische Daten] [G. Talarico, G. Tosto, S. Pietracupa, E. Piacentini, M. Canevelli, G. Lenzi, G. Bruno] The serotonin toxicity (ST) is a potentially life-threatening adverse drug reaction results from therapeutic drug use, intentional self-poisoning, or inadvertent interactions between drugs. ST can be caused by a single or a combination of drugs with serotonergic activity due to excessive serotonergic agonism on central nervous system and peripheral serotonergic receptors (monoamine oxidase inhibitors, tricyclic antidepressants, SSRIs, opiate analgesics, over-the-counter cough medicines, antibiotics, weight-reduction agents, antiemetics, antimigraine agents, drugs of abuse, H2-antagonist and herbal products). The serotonin toxicity is often described as a clinical triad of mental-status changes (agitation and excitement with confusion), autonomic hyperactivity (diaphoresis, fever, tachycardia, and tachypnea), neuromuscular abnormalities (tremor, clonus, myoclonus, and hyperreflexia) and, in the advanced stage, spasticity; not all of these findings are consistently present. In this article, we describe two cases of ST due to interaction between Citalopram and two CYP2D6 inhibitors: Cimetidine and Topiramate and their clinical resolution after treatment discontinuation. Springer-Verlag, 2011 Serotonin toxicity nationallicence Citalopram nationallicence Cimetidine nationallicence Topiramate nationallicence Drug interaction nationallicence Neuroleptic nationallicence Malignant syndrome nationallicence Talarico G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Tosto G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Pietracupa S. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Piacentini E. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Canevelli M. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Lenzi G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Bruno G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut Neurological Sciences Springer Milan 32/3(2011-06-01), 507-509 1590-1874 32:3<507 2011 32 10072 https://doi.org/10.1007/s10072-011-0546-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0546-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Talarico G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Tosto G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Pietracupa S. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Piacentini E. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Canevelli M. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Lenzi G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Bruno G. Memory Clinic, Department of Neurological Science, University "La Sapienza”, Viale dell'Università 30, 00185, Rome, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/3(2011-06-01), 507-509 1590-1874 32:3<507 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer