caa a22 4500 445356278 CHVBK 20180317142901.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10072-011-0481-z doi (NATIONALLICENCE)springer-10.1007/s10072-011-0481-z Chronic acquired hepatocerebral degeneration: effects of liver transplantation on neurological manifestations [Elektronische Daten] [A. Stracciari, E. Baldin, L. Cretella, L. Delaj, R. D'Alessandro, M. Guarino] Three cirrhotic patients with chronic acquired hepatocerebral degeneration (CAHD) received neurologic, neuropsychologic and neuroimaging assessment before and after liver transplantation (LT). Before transplantation, neurologic dysfunction consisted in severe bradykinesia, dystonia, dyskinesia, ataxia and dysarthria. Cognitive impairment affected mainly attentional and executive domains. Brain MRI showed bilateral hyperintensities of the basal ganglia on T1-weighted images. After transplantation, motor manifestations promptly resolved. Cognitive testing showed a major improvement in two patients, whereas cognitive performances were slightly worsened in the third, reasonably due to the effects of a head injury before LT and a tacrolimus-related encephalopathy arising early after LT. MRI images12months later showed a slight reduction of the previously disclosed abnormalities in all three patients. None of them experienced recurrence of CAHD. Our observation reinforces the assumption that surgery is the best treatment option for CAHD and that severe neurological impairment in CAHD should not be considered a contraindication for LT. Springer-Verlag, 2011 Chronic acquired hepatocerebral degeneration nationallicence Movement disorders nationallicence Cognitive impairment nationallicence Liver transplantation nationallicence Stracciari A. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut Baldin E. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut Cretella L. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut Delaj L. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut D'Alessandro R. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut Guarino M. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut Neurological Sciences Springer Milan 32/3(2011-06-01), 411-415 1590-1874 32:3<411 2011 32 10072 https://doi.org/10.1007/s10072-011-0481-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10072-011-0481-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stracciari A. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 700 1- Baldin E. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 700 1- Cretella L. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 700 1- Delaj L. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 700 1- D'Alessandro R. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 700 1- Guarino M. Unità Operativa di Neurologia, Azienda Ospedaliero-Universitaria S.Orsola-Malpighi, via Albertoni 15, 40138, Bologna, Italy aut NATIONALLICENCE 773 0- Neurological Sciences Springer Milan 32/3(2011-06-01), 411-415 1590-1874 32:3<411 2011 32 10072 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer